Efficacy of Autologous Platelet-Rich Plasma Use for Orthopaedic Indications JBJS

Two recent JBJS publications, Efficacy of Autologous Platelet-Rich Plasma Use for Orthopaedic Indications: A Meta-Analysis and Platelet-Rich Plasma Differs According to Preparation Method and Human Variability are relevant to the rapidly increasing interest in PRP for the management of musculoskeletal disorders. In short, the first article reports that in spite of 33 high quality studies, there remains uncertainty about the effectiveness of PRP in the management of disorders such as rotator cuff injuries - basically, the results were just too variable to determine if there was or was not a beneficial effect.

The second article indicates that the different preparations of PRP are quite variable.

We'll have to continue to observe this evolving area to see what sorts out as more high quality studies with the different preparations become available. 

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