He was particularly interested in proving causation; he developed nine criteria and used them to convince the scientific community that smoking caused cancer. Here are the Hill Criteria:
(1) the strength of the association
(2) the consistency of the observed association
(3) the specificity of the association
You may be interested in his writing "The Environment and Disease: Associationor Causation?"
He concludes this article with the following 'poke' at those of us who excessively emphasize "p<":
(1) the strength of the association
(2) the consistency of the observed association
(3) the specificity of the association
(4) the temporal relationship of the association
(5) the biological gradient (dose/response relationship)
(6) the biological plausibility – the mechanism by which local anesthetics cause chondrolysis is consistent with the current understanding of mechanisms of cytotoxicity;
(7) coherence - does the cause-and-effect interpretation of the data conflict with the generally known facts of the natural history and biology?
(8) experimental evidence
(9) analogy
(5) the biological gradient (dose/response relationship)
(6) the biological plausibility – the mechanism by which local anesthetics cause chondrolysis is consistent with the current understanding of mechanisms of cytotoxicity;
(7) coherence - does the cause-and-effect interpretation of the data conflict with the generally known facts of the natural history and biology?
(8) experimental evidence
(9) analogy
You may be interested in his writing "The Environment and Disease: Associationor Causation?"
He concludes this article with the following 'poke' at those of us who excessively emphasize "p<":
Of course I exaggerate. Yet too often I suspect we waste a deal of time, we grasp the shadow and lose the substance, we weaken our capacity to interpret the data and to take reasonable decisions whatever the value of P. And far too often we deduce ‘no difference’ from ‘no significant difference.’ Like fire, the chi-squared test is an excellent servant and a bad master.”
Makes one think.....
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If you have suggestions for topics you'd like us to address in this blog, please send an email to
shoulderarthritis@uw.edu
Use the "Search the Blog" box to the right to find other topics of interest to you.
You may be interested in some of our most visited web pages including:shoulder arthritis, total shoulder, ream and run, reverse total shoulder, CTA arthroplasty, and rotator cuff surgery.
See the countries from which our readers come on this post.