This paper demonstrates in a rat model that sclerosin antibody enhances mechanical fixation of medullary implants by increasing cortical and trabecular bone volume.
The authors point out that total joint failure is a growing problem and suggest that stem loosening is a major cause of revision surgery. They also suggest that strategies for enhancing implant fixation includes the use of growth factors (BMP and TGF beta) and agents such as parathyroid hormone.
While this drug based therapies may prove to be of value, we have found that the most solid, immediate, enduring and cost-effective approach for increasing bone volume and enhancing implant fixation is through impaction autografting as shown here.
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