Popular Posts
- Artificial intelligence will facilitate clinically important shoulder arthroplasty research
- The pilot/the surgeon is the method
- Ream and Run - the rehab program
- ChatGPT, the shoulder arthritis blog, and me
- Our orthopaedic judgment is flawed by noise
- Shoulder exercises
- Does postoperative glenoid version matter in anatomic total shoulder arthroplasty? The jury is in.
- What type of rTSA should I use and how should I position it? Insights from 13 Recent Studies On Prosthesis and Position
- How to access, follow and enjoy this blog
- The Axillary view = the 'truth' view
Thursday, November 28, 2013
Narcotics may interfere with bone healing
Postoperative Opioid Administration Inhibits Bone Healing in an Animal Model
The authors observe that opiod medications are the mainstay of orthopaedic pain control. They used a rat fracture model to evaluate the effects of opioid administration on bone union in an operatively stabilized fracture. After a 0.4-mm femoral osteotomy gap was created, rats were randomized to control versus morphine-treated study groups.
There was a statistically significant (p = 0.048) reduction in callus strength in morphine-treated animals 8 weeks postoperatively compared with controls. Radiographic and histological analysis showed delayed callus maturation and lack of remodeling in the morphine group compared with control animals at 8 weeks.
The authors concluded that administration of an opioid pain medication leads to weaker callus and impedes callus maturation compared with controls.
Comment: In fracture cases as well as in shoulder arthroplasty, bone healing and remodeling are important. The authors have given us yet another reason to consider minimizing our use of narcotics.
===
Consultation for those who live a distance away from Seattle.
**Check out the new (under construction) Shoulder Arthritis Book - click here.**
To see the topics covered in this Blog, click here
Use the "Search" box to the right to find other topics of interest to you.
You may be interested in some of our most visited web pages including:shoulder arthritis, total shoulder, ream and run, reverse total shoulder, CTA arthroplasty, and rotator cuff surgery as well as the 'ream and run essentials'.
See from which cities our patients come.
See the countries from which our readers come on this post.