Thursday, November 28, 2013

Narcotics may interfere with bone healing

Postoperative Opioid Administration Inhibits Bone Healing in an Animal Model

The authors observe that opiod medications are the mainstay of orthopaedic pain control. They used a rat fracture model to evaluate the effects of opioid administration on bone union in an operatively stabilized fracture. After a 0.4-mm femoral osteotomy gap was created, rats were randomized to control versus morphine-treated study groups.

There was a statistically significant (p = 0.048) reduction in callus strength in morphine-treated animals 8 weeks postoperatively compared with controls. Radiographic and histological analysis showed delayed callus maturation and lack of remodeling in the morphine group compared with control animals at 8 weeks.

The authors concluded that administration of an opioid pain medication leads to weaker callus and impedes callus maturation compared with controls.

Comment: In fracture cases as well as in shoulder arthroplasty, bone healing and remodeling are important. The authors have given us yet another reason to consider minimizing our use of narcotics.

Consultation for those who live a distance away from Seattle.

**Check out the new (under construction) Shoulder Arthritis Book - click here.**

To see the topics covered in this Blog, click here

Use the "Search" box to the right to find other topics of interest to you.

You may be interested in some of our most visited web pages including:shoulder arthritis, total shoulder, ream and run, reverse total shoulder, CTA arthroplasty, and rotator cuff surgery as well as the 'ream and run essentials'.

See from which cities our patients come.

See the countries from which our readers come on this post.