Popular Posts
- Do lateralization and distalization after reverse total shoulder have a clinically significant relationship with patient outcome?
- Managing the B2 glenoid in a 73 year old pistol instructor: RnR vs RFE?. Six year followup.
- Technique vs technology: managing a B2 glenoid in an active 67 year old woman. 9 year followup
- Shoulder exercises
- Bilateral B2 glenoids in a 70+ year old man. Anatomic total shoulder or RFE? 10 year followup
- X-rays for shoulder arthritis
- Rotator cuff tears and Deca Durabolin Anabolic Steroids
- The ream and run - the CRITICAL first 6 weeks of rehabilitation
- Managing the shoulder of a 68 year old active man with a B2 glenoid? RFE?
- Sad news about the management of severe cuff tear arthropathy (E3, IIA, 4B) in a 71 year old man.
Thursday, November 28, 2013
Narcotics may interfere with bone healing
Postoperative Opioid Administration Inhibits Bone Healing in an Animal Model
The authors observe that opiod medications are the mainstay of orthopaedic pain control. They used a rat fracture model to evaluate the effects of opioid administration on bone union in an operatively stabilized fracture. After a 0.4-mm femoral osteotomy gap was created, rats were randomized to control versus morphine-treated study groups.
There was a statistically significant (p = 0.048) reduction in callus strength in morphine-treated animals 8 weeks postoperatively compared with controls. Radiographic and histological analysis showed delayed callus maturation and lack of remodeling in the morphine group compared with control animals at 8 weeks.
The authors concluded that administration of an opioid pain medication leads to weaker callus and impedes callus maturation compared with controls.
Comment: In fracture cases as well as in shoulder arthroplasty, bone healing and remodeling are important. The authors have given us yet another reason to consider minimizing our use of narcotics.
===
Consultation for those who live a distance away from Seattle.
**Check out the new (under construction) Shoulder Arthritis Book - click here.**
To see the topics covered in this Blog, click here
Use the "Search" box to the right to find other topics of interest to you.
You may be interested in some of our most visited web pages including:shoulder arthritis, total shoulder, ream and run, reverse total shoulder, CTA arthroplasty, and rotator cuff surgery as well as the 'ream and run essentials'.
See from which cities our patients come.
See the countries from which our readers come on this post.