This is an important question to which the answer is currently unknown. The article linked above provides a good summary of the state of knowledge as of today.
In our 40 years of practice we have not recognized a case of metal allergy to the implants we use.
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You may be interested in some of our most visited web pages including:shoulder arthritis, total shoulder, ream and run, reverse total shoulder, CTA arthroplasty, and rotator cuff surgery as well as the 'ream and run essentials'
