Monday, December 29, 2014

Hyperglycemia may facilitate biofilm formation

Biofilm growth has a threshold response to glucose in vitro.

These authors used an in vitro model of biofilm formation to investigate the relationship between the amount of biofilm formed by Staphylococcus epidermidis and Staphylococcus aureus and the glucose concentration in the clinically important range of 20 to 300 mg/dL.

They found increased biofilm growth by S aureus and S epidermidis in the clinically important range of 20 to 300 mg/dL.

They concluded that postoperative hyperglycemia may increase the risk for implant infection through increased pathogenicity of intraoperative wound contaminants in addition to compromising host immune status.

Comment: This is an example of how a change in the host environment may increase the pathogenicity of bacteria.

Optimizing the blood glucose after shoulder surgery may reduce the chances of biofilm formation.


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