How survivorship bias can affect reports of two-year outcomes
When we quote a two-year success rate for an operation, the figure typically describes the outcomes for the patients who came back to be assessed at two or more years after surgery.
Those who did not return are not a random sample of all the patients having the surgery. Patients lost to follow-up tend to have fared worse than those who complete follow-up, because the reasons they drop out are often themselves adverse — death, revision, or disappointment with an early result that leads them to transfer their care elsewhere [1, 2, 3].
Excluding patients who have done poorly prior to the two-year mark — considering only those who remain for the two-year analysis — makes the operation look better than it actually was, a phenomenon known as survivorship bias [4].
A model of survivorship bias
Here is an illustrative hypothetical example of a thousand patients having an RSA for cuff-intact osteoarthritis with two-year follow-up.
In the first six months patients were lost as follows: 20 shoulders revised, 5 patients dead, 15 transferred to another practice, and 40 who simply stopped responding — 80 in all. Of note, certain problems occur early in the postoperative period: acute infection, instability, acromial fracture, and life-limiting frailty.
During the second six months there were 7 more revisions and 8 deaths, 25 transfers, and 110 who did not respond for unknown reasons — 150 in the interval.
The second-year losses are almost entirely loss of contact rather than loss of the shoulder: 3 revised and 12 more dead, 35 gone to other practices, and 200 more who stopped answering — 250 in that interval.
By the time of the two-year analysis, 30 of the 1,000 have been revised, 25 have died, and 75 have transferred their care; 350 more have gone quiet without a recorded reason. That is 480 lost from view, none of whom are included in the two-year analysis of results; only 520 remain available for study.
Figure 1. A hypothetical cohort of 1,000 patients followed over two years. At each interval, patients drop out of view for four kinds of reasons, and the mix changes as time passes. Of the 520 analyzed at two years, 9 out of 10 report success; but out of all 1,000 operated on, a successful outcome is documented for only about 4.7 out of every 10.
The four reasons carry different weight, and their proportions change over the two years. Revisions come early: RSA’s dominant early failures — acute infection, instability, and acromial fracture — appear mostly in the first months, so revisions decline from 20 in the first half-year to 3 in the second year. Deaths run the other way, accumulating with time in an elderly group, from 5 to 8 to 12 across the intervals. Transfers of care, and above all patients who simply stop responding, grow steadily as contact is lost — from 40 silent patients in the first six months to 200 in the second year. By the time of the two-year analysis, loss of contact, not loss of the shoulder, accounts for most of the missing.
Applying the model of survivorship bias to actual data on two-year outcomes for RSA for osteoarthritis
The model becomes meaningful when anchored to what the literature reports. Two published figures set the scale.
The first is the rate of two-year follow-up. In a multicenter shoulder arthroplasty registry, only about half of patients — about 5 out of 10 — provided two-year patient-reported outcomes [5]; registries that send repeated reminders might improve the return to 8 out of 10.
The second is the success rate among those who do return: in high-volume single-surgeon series of RSA for this diagnosis, about 9 out of 10 report being better and satisfied [6, 7].
Consider the combined effect of these two rates. Of the 520 with a known two-year result, 9 out of 10 — 468 patients — report success; but across the full 1,000 who had the surgery, those 468 provide an overall documented success rate of only about 4.7 out of 10.
Had the follow-up rate reached 8 out of 10 rather than 5, about 800 would have a known result, and the same 9 out of 10 would give about 720 documented successes — roughly 7 out of 10.
The span from 4.7 to 7 out of 10 is set entirely by the follow-up rate.
The 4.7 out of 10 is the floor. It counts every patient without a documented success as a non-success, so that the true whole-cohort success rate (if it could be known) might be higher than 4.7 out of 10.
The missing patients are not a random subset of the cohort. Those lost to revision, death, or a transfer of care each had reason to fare worse than the returners. The larger unresponsive group has, on average, done less well than those who answer — though that association is weaker and less certain than for the other types of losses [1, 2, 3].
Reporting the returners’ 9 out of 10 as the rate for the overall cohort makes the operation look better than the data support [4].
However, a successful outcome is only documented for about 5 of every 10 patients considering all those having the surgery, not 9 out of 10.
A fuller accounting would mean following the patients who leave — the revised, the transferred, and above all the ones who quietly stop answering — well enough to know how they actually did. Until a series does that, the appropriate two-year estimate for successful outcome for RSA in osteoarthritis is somewhere above the documented 4.7 out of 10 rate for the entire cohort and below the rate of 9 out of 10 considering only the patients returning for two year analysis.
And two years is the favorable case. The effect of survivorship bias grows as follow-up lengthens: over five, ten, and fifteen years, follow-up falls further and the number of missing patients grows, so the distance between the returners’ success rate and the whole-cohort success rate only widens. The longer the follow-up a reported success rate claims, the greater the effect of survivorship bias.
It's about survivorship
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References
[1] Solberg TK, Sørlie A, Sjaavik K, Nygaard ØP, Ingebrigtsen T. Would loss to follow-up bias the outcome evaluation of patients operated for degenerative disorders of the lumbar spine? A study of responding and non-responding cohort participants from a clinical spine surgery registry. Acta Orthop. 2011;82(1):56–63.
[2] Murnaghan ML, Buckley RE. Lost but not forgotten: patients lost to follow-up in a trauma database. Can J Surg. 2002;45(3):191–195.
[3] Torrens C, Martínez R, Santana F. Patients lost to follow-up in shoulder arthroplasty: descriptive characteristics and reasons. Clin Orthop Surg. 2022;14(1):112–118.
[4] Elston DM. Survivorship bias. J Am Acad Dermatol. Published online June 18, 2021.
[5] Patel M, Sekar MG, McDaniel L, Kisana HM, Sykes JB, Amini MH. Changes from baseline in patient-reported outcomes and patient satisfaction do not vary significantly between 1 and 2 years postoperatively after shoulder arthroplasty: a multicenter analysis of 2580 patients. Semin Arthroplasty JSES. 2025;35(2):235–245.
[6] Puzzitiello RN, Moverman MA, Glass EA, Swanson DP, Bowler AR, Le K, Kirsch JM, Lohre R, Jawa A. Clinically significant outcome thresholds and rates of achievement by shoulder arthroplasty type and preoperative diagnosis. J Shoulder Elbow Surg. 2024;33(7):1448–1456.
[7] Ahmed AF, Glass EA, Swanson DP, et al. Predictors of poor and excellent outcomes following reverse shoulder arthroplasty for glenohumeral osteoarthritis with an intact rotator cuff. J Shoulder Elbow Surg. 2024;33(6S):S55–S63.
Here are some takeaways from that presentation coupled with some additional thoughts from the U.W..
(1) The evolution in humeral components is attributed to (a) mitigation of complications (periprosthetic fracture, stress shielding from high canal-filling ratios, early loosening from certain ingrowth surfaces), (b) matching competitor features, and (c) responding to market forces.
The Standard Stem
(2) A standard length stem uses the canal as an alignment guide. It can be stabilized in the canal by (a) a bony ingrowth surface, (b) cement, or (c) reaming to a tight diaphyseal fit, reaming that, in any case, removes cortical bone asymmetrically and unpredictably. [7]. As discussed later in this post, the standard stem can also be stabilized in the canal by impaction grafting. Much of the stress-shielding literature conflates two different things — stem length and canal fill — and they are not the same. Proximal stress shielding tracks with the filling ratio — how much of the canal the implant occupies and how much load it diverts away from proximal bone — far more than with the absolute length of the stem. [9,10]. A long stem that fills the canal shields bone; a long stem that sits loosely in the canal, transferring load through impacted cancellous bone, need not.
(3) Osteoporosis or altered humeral anatomy may drive the use of a longer stem for better fixation and durability.
The Short Stem
(4) The short stem depends on loading at the metaphyseal level — in bone of variable shape and quality — making both fixation and orientation challenging.
Canal filling can lead to stress shielding
(5) Stemless implants depend on fixation at the anatomic neck, where a thin cortical shell surrounds cancellous bone. Bone density at this level is of variable quality, especially in patients in the arthroplasty age range. While some surgeons claim “100% stemless,” that claim is not realistic for every patient having shoulder arthroplasty.
AP radiograph with the anatomic-neck fixation zone annotated
Avoiding Trouble with the Stemless
Be aware of common technical mistakes - assure complete head resection and avoid excessive varus or valgus.
Insufficient head resection
Varus cut
The free-hand cut is key.
Revision
(6) Two concerns arise when the humeral component needs revision. First, removal of a well-fixed implant can risk fracture of the tuberosity, bone loss, and shaft fracture, and may require a humeral osteotomy or window. Second, although some humeral implants are “convertible” (the humeral fixation system stays in place), retaining the implant only makes sense if it is well fixed at an appropriate height and acceptable version. One podcast participant reported that 25–40% of nominally convertible stems cannot actually be converted in practice. Taken together, the routine use of “convertible” implants seems unattractive.
Malrotation
Another approach
(7) Our experience is that secure, safely revisable humeral component fixation can be achieved with a smooth, standard-length stem set at a small filling ratio and fixed with impaction autografting — using bone from the resected humeral head that one of our fellows named “God’s Own Glue” (see "Procrustean Method") [2,3]. The graft is impacted between a smooth stem and the endosteal cortex, where it stabilizes the implant at the time of surgery, rather than relying on a bony ingrowth surface, cement, or a tight diaphyseal press fit. [4]. A low filling ratio protects the humerus from stress shielding. Because the stem is deliberately undersized, load is transferred through grafted cancellous bone rather than bypassed down a canal-filling implant — addressing stress shielding at the variable that drives it. [9,10].
In 48 ream-and-run and 78 total shoulder arthroplasties using a smooth, standard-length impaction-grafted stem, two-year radiographs showed adaptive changes that were generally minor and not associated with component shift or subsidence. Inserted this way, a smooth standard-length stem offers secure, bone-preserving fixation providing results can serve as a basis for comparison for other component designs and fixation methods. [5].
In a consecutive single-surgeon series of 458 anatomic total shoulder arthroplasties using this construct (mean follow-up 9.2 years; 114 shoulders beyond ten years), Simple Shoulder Test scores improved from 3.3 to 9.2 and were sustained — never declining by more than the MCID — past ten years. The overall revision rate was 2.6% (12 of 458). None of the revisions were performed for a humeral-component cause: there was no humeral component loosening, no periprosthetic fracture, and no stem-related failure.[11]
A low filling ratio protects the humerus from stress shielding
Six year followup
Impaction grafting with a low filling ratio avoids incomplete seating of the humeral stem (humerus captivus)
1. The ASES Podcast (American Shoulder and Elbow Surgeons), Episode 155: standard, short, and stemless humeral components and convertible designs. Available at: https://www.youtube.com/watch?v=q_s_g8oQgPg
2. Razfar N, Reeves JM, Langohr GDG, Willing R, Athwal GS, Johnson JA. Comparison of proximal humeral bone stresses between stemless, short stem, and standard stem length: a finite element analysis. J Shoulder Elbow Surg. 2016;25(7):1076–1083. doi:10.1016/j.jse.2015.11.011. PMID 26810016.
3. Reeves JM, Langohr GDG, Athwal GS, Johnson JA. The effect of stemless humeral component fixation feature design on bone stress and strain response: a finite element analysis. J Shoulder Elbow Surg. 2018;27(12):2232–2241. doi:10.1016/j.jse.2018.06.002. PMID 30104100.
4. Synnott S, Langohr GDG, Reeves JM, Johnson JA, Athwal GS. The effect of humeral implant thickness and canal fill on interface contact and bone stresses in the proximal humerus. JSES Int. 2021;5(5):881–888. doi:10.1016/j.jseint.2021.05.006.
5. Aibinder WR, Uddin F, Bicknell RT, Krupp R, Scheibel M, Athwal GS. Stress shielding following stemless anatomic total shoulder arthroplasty. Shoulder Elbow. 2023. doi:10.1177/17585732211058804. PMID 36895609.
6. Raiss P, Edwards TB, Deutsch A, Shah A, Bruckner T, Loew M, Boileau P, Walch G. Radiographic changes around humeral components in shoulder arthroplasty. J Bone Joint Surg Am. 2014;96(7):e54. doi:10.2106/JBJS.M.00378. PMID 24695931.
7. Denard PJ, Raiss P, Gobezie R, Edwards TB, Lederman E. Stress shielding of the humerus in press-fit anatomic shoulder arthroplasty: review and recommendations for evaluation. J Shoulder Elbow Surg. 2018;27(6):1139–1147. doi:10.1016/j.jse.2017.12.020. PMID 29422391.
8. Sheth MM, Kahsai EA, Yang J, Whitson AJ, Matsen FA III, Hsu JE. What is the clinical importance of radiographic changes around the humeral component in anatomic shoulder arthroplasty? A minimum 4-year follow-up study. J Shoulder Elbow Surg.2025;34(8):1877–1885. doi:10.1016/j.jse.2024.11.024. PMID 39800107.
9. Denard PJ, Hsu JE, Whitson A, Neradilek MB, Matsen FA III. Radiographic outcomes of impaction-grafted standard-length humeral components in total shoulder and ream-and-run arthroplasty: is stress shielding an issue? J Shoulder Elbow Surg.2019;28(11):2181–2190. doi:10.1016/j.jse.2019.03.016. PMID 31272887.
10. Kim SC, Park JH, Bukhary H, Yoo JC. Humeral stem with low filling ratio reduces stress shielding in primary reverse shoulder arthroplasty. Int Orthop. 2022;46(6):1341–1349. doi:10.1007/s00264-022-05383-4.
11. Lee M, Chebli C, Mounce D, Bertelsen A, Richardson M, Matsen FA III. Intramedullary reaming for press-fit fixation of a humeral component removes cortical bone asymmetrically. J Shoulder Elbow Surg. 2008;17(1):150–155. doi:10.1016/j.jse.2007.03.032. PMID 18029200.
12. Boorman RS, Hacker SA, Lippitt SB, Matsen FA III. A conservative broaching and impaction grafting technique for humeral component placement and fixation in shoulder arthroplasty: the Procrustean method. Tech Shoulder Elbow Surg.2001;2(3):166–175. doi:10.1097/00132589-200109000-00004.
13. Hacker SA, Boorman RS, Lippitt SB, Matsen FA III. Impaction grafting improves the fit of uncemented humeral arthroplasty. J Shoulder Elbow Surg. 2003;12(5):431–435. doi:10.1016/s1058-2746(03)00053-3. PMID 14564262.
14. Lucas RM, Hsu JE, Gee AO, Neradilek MB, Matsen FA III. Impaction autografting: bone-preserving, secure fixation of a standard humeral component. J Shoulder Elbow Surg. 2016;25(11):1787–1794. doi:10.1016/j.jse.2016.03.008. PMID 27262410.
15. Lee et al. Stress shielding effects of short stem alignment and bone density in reverse shoulder arthroplasty. J Orthop Res. 2026. doi:10.1002/jor.70140.
16. Vasiliadis AV, Giovanoulis V, Lepidas N, Bampis I, Servien E, Lustig S, Gunst S. Stress shielding in stemmed reverse shoulder arthroplasty: an updated review. SICOT J. 2024;10:37. doi:10.1051/sicotj/2024029.
17. Ritter D, Raiss P, Denard PJ, Werner BC, Müller PE, Woiczinski M, Wijdicks CA, Bachmaier S. Volumetric humeral canal fill ratio effects primary stability and cortical bone loading in short and standard stem reverse shoulder arthroplasty: a biomechanical and computational study. J Imaging. 2024;10(12):334. doi:10.3390/jimaging10120334.
18. Kramer M, Olach M, Zdravkovic V, Manser M, Raiss P, Jost B, Spross C. The effects of length and width of the stem on proximal humerus stress shielding in uncemented primary reverse total shoulder arthroplasty. Arch Orthop Trauma Surg. 2024. doi:10.1007/s00402-023-05129-w.
19. John PB, Nageswaran S. Mechanobiological evaluation of solid and multiple porous humeral stem architectures in reverse shoulder arthroplasty based on design and materials: a finite element study. Front Bioeng Biotechnol. 2026;13:1675726. doi:10.3389/fbioe.2025.1675726.
20. Takayama K, Ito H. Association between the canal filling ratio and bone resorption in trabecular metal stems in reverse total shoulder arthroplasty: a radiographic analysis using tomosynthesis. JSES Int. 2024;8(5):1077–1086. doi:10.1016/j.jseint.2024.05.010.
Conclusion
The evidence answers both opening questions.
First, patient-reported outcomes after shoulder arthroplasty have improved over the past decade — modestly, and by an amount that reaches the MCID only when accumulated across the period, not within any single year.
Second, two different questions hide inside "what is the change associated with," and they have different answers.
(A) The decade-long trend is real but cannot be apportioned by the available data; it is most plausibly the product of accumulated surgeon experience, refinements in technique, rehabilitation, and perioperative care. The case mix did not drift toward easier shoulders [8], and no individual technology was associated with the improved outcomes over the decade [4].
(B) The other question — what determines the result for an individual patient — has a clearer answer. The available evidence has not shown a patient-reported benefit from any technology assessed, nor from any change in the shoulders we treat. Surgeon volume and training affect revision and complication rates, but not, as far as the data show, the patient-reported result. That leaves the patient: selection, optimization of modifiable risk, socioeconomic context, and resilience.
The greatest demonstrated effect on the outcome therefore lies in choosing and preparing the patient; the experience the surgeon brings to the procedure most likely matters too, though these data cannot show by how much.
Market forces are clearly driving orthopaedic companies to develop new implants and technologies that strengthen their competitive position, even though evidence that these have a major impact on patient outcomes is lacking.
What this analysis does offer, though, is actionable intelligence: the surest routes to improving outcomes for our patients are (1) thoughtful patient selection and optimization and (2) education that enables surgeons to improve their craft of shoulder arthroplasty.