Monday, June 8, 2026

Pyrocarbon Section 4: clinical data


In this post we take a bit of a deeper dive into the clinical information available regarding pyrocarbon humeral arthroplasty - looking at evidence from the Australian and New Zealand registries alongside the currently available reports on specific cohorts.

Please note that this is a "best effort" attempt to put together what's out there. If the reader finds any of this to be in error, please do let me know.


Newspaper-style, the post starts with a summary

and then presents data that may support the points presented in the summary.


1. There is no single “pyrocarbon shoulder” — there are at least three. Resurfacing (PyroTITAN, not FDA-cleared in the U.S.), the U.S. FDA-cleared stemmed pyrocarbon hemiarthroplasty, and the European stemmed hemiarthroplasty with systematic head-downsizing. Each uses different implants or different techniques; a finding for one may not transfer to another, and pooling them is a common error in this literature.

2. Registries present data on revision rate, not function. McBride 2026, the AOANJRR 2025 special clinical assessment, and the New Zealand registry agree that pyrocarbon is revised about as often as a good anatomic TSA. However revision is a surrogate endpoint: the observation that a patient's implant was not revised does not necessarily mean that the patient had good shoulder comfort and function (we know this from reverse total shoulders where patients living with poor postoperative comfort and function often do not have revision surgery).  What matters most to the patient and to us is the degree to which the arthroplasty improved the patient's quality of life.

3. The currently available data often do not relate to implants and techniques currently in use. Most series are based heavily on approaches no longer in play today.

4. Where patient-reported outcomes exist, they show - like just about every other type of shoulder arthroplasty - clinically significant improvement over the preoperative state that lasts 5–10 years. Appropriately controlled studies that compare clinical outcomes for pyrocarbon humeral arthroplasty to other surgical options for managing glenohumeral arthritis are, however, uncommon.

5. The one head-to-head functional comparison still favors total over hemiarthroplasty early on. In the New Zealand registry, anatomic TSA surpassed pyrocarbon hemi on the Oxford score at both 6 months and 5 years. Notably, the functional advantage of total over hemi is not eliminated by changing the use of pyrocarbon bearing surface.

6. Royalties or research funding from pyrocarbon implant manufacturers are disclosed in many of the cohort series.  That does not invalidate the data, but it is recognized that industrial support can affect study design, data analysis and conclusions.

7. The bearing surface is not the most important aspect of the reconstruction. As is the case for all other types of shoulder arthroplasty, the outcome of pyrocarbon arthroplasty is critically dependent on patient selection, component size, component positioning, glenoid management, soft tissue balancing, and rehabilitation.

Future clinical research will hopefully define the indications, the appropriate implants, the surgical technique, and the clinical outcomes for pyrocarbon humeral arthroplasty.


Now for the details

Two Australian Orthopaedic Association (AOANJRR) analyses: two different pyrocarbon devices. Both draw on the AOA registry, but they study different pyrocarbon configurations. Both presen revision/survivorship endpoints with no patient-reported outcomes.

1. McBride presents the pyrocarbon humeral hemi-resurfacing (PHR/PyroTITAN — a resurfacing cap, no head excision, the Australian research-restricted device that is not FDA-cleared for use in the U.S.), comparing PHR in patients <65 versus the five lowest-CPR (cumulative percent revision) aTSA combinations.

2. The AOA Annual Report also presents data on a hemi stemmed pyrocarbon implant. That stemmed configuration is basically the same as the U.S.-cleared device and the European (Boileau) stemmed construct.

To complement these registry studies, cohort reports concern the three pyrocarbon devices in current use: (1) resurfacing (PHR/PyroTITAN); (2) the U.S. stemmed hemiarthroplasty (FDA-cleared Tornier/Stryker); and (3) the Boileau/European stemmed hemiarthroplasty. Devices 2 and 3 share the same hardware (Aequalis Ascend Flex stem + pyrocarbon head) but have separate literature, study designs, and technique: the Boileau approach systematically downsized the component.

In the table above, each cell carries a generation/technique caveat: the long-term numbers may not describe the devices and techniques commonly used today.


AOANJRR 2025

The AOANJRR 2025 “hemi stemmed anatomic — pyrocarbon head” class does not differentiate U.S. vs Boileau technique.  This Annual Report compares four shoulder arthroplasty classes in patients under 60 with OA, restricted to prostheses still implanted in 2024 (the “modern prostheses” filter), with data to 31 December 2024. 


Note that the confidence intervals for all four classes overlap. Adjusted for age and sex, no comparison to the pyrocarbon hemi reached significance. The executive summary states it plainly: “a hemi stemmed anatomic with a pyrocarbon head was not different to traditional total shoulder replacement options in this age group.” The report contains no patient reported outcome data.

New Zealand National Joint Registry

Gao and colleagues reported the 159 stemmed pyrocarbon hemiarthroplasties (PyCHAs (Tornier Flex stem, pyrocarbon head) against 1,280 conventional metal HAs and 4,285 aTSAs. Importantly, average follow-up was shorter for PyCHA (3.3 yr vs 12.7 and 8.3). With this caveat, PyCHA retention (96.9%) was comparable to aTSA in patients under 60 and better than conventional metal HA on both retention and Oxford Shoulder Score. aTSA had numerically better Oxford scores than PyCHA at 6 months and 5 years.

Clinical outcomes and revision rates by device — the cohort series

The cohort series add what the registries omit — but they are single-arm, small, and almost all industry-linked. The registry analyses above report revision only; none measures a patient-reported outcome. The published cohort series below supply PROs, range of motion, and graded glenoid erosion — but each one is a single-arm case series (Level IV, no comparator), the largest is ~100 shoulders; follow-up is short-to-intermediate. They establish that each device improves shoulder scores against the patient’s own baseline; however, they do not establish superiority over aTSA or any other glenoid-sparing alternative. 


Resurfacing (PHR):  the contemporary third-generation resurfacing implant specifically has neither long-term revision nor any PRO follow-up. 

Hemiarthroplasty — US: the U.S. experience with the currently available implant is anchored by Griswold 2025 (JBJS), drawn from the Stryker pyrocarbon IDE cohort plus a subsequent prospective follow-up: 45 patients at a mean 73 months. Every PRO improved past MCID (ASES 47->96, Constant 48->88, SANE 39->94, VAS pain 5.0->0.2), satisfaction was 97.8%, and 7-year revision-free survival was 95.7% — both revisions for infection, none for glenoid erosion or breakage. 

Hemiarthroplasty — Boileau / European: the largest, longest evidence. The European stemmed device is the same Ascend Flex + pyrocarbon-head hardware as the U.S. implant, but placed with systematic head downsizing, anchored by the Boileau (Nice) and Garret/Godenèche (Lyon) groups, and corroborated by two independent European centers.

Cointat 2022 (64 shoulders, 92% survival at 3 yr), Garret 2024 (45 patients, 4.4% revision, scores maintained at 5–9 yr), and Boileau 2026 (103 shoulders, revision-free 94% at 5 yr and 89% at 10 yr) consistently show Constant rising from the mid-30s to ~80, SSV from ~35 to ~84, and return to work and sport above 90%. Mathon 2023 (Marseille; 41 shoulders, Constant 34->80 at 3 yr, 100% return to work, glenoid wear <0.6 mm on CT 3D modeling, no revisions) and Kleim 2024 (Munich/Agatharied; 31 shoulders, Constant 45->79 sustained to 5.5 yr, MCID surpassed in every diagnosis, medial glenoid erosion only ~0.3 mm/yr after a biphasic first year, 100% survival).  Kleim independently reproduced Boileau’s finding that glenoid reaming does not drive more erosion. 

The dominant, reproducible failure mechanism across the series was humeral-head oversizing: the pyrocarbon head sits ~2 mm proud of a metal head of equal diameter (a 1.5-mm support tray plus a 0.5-mm taper gap), nonanatomic reconstruction occurred in 24–29% of cases, and in Boileau’s series nonanatomic reconstruction carried a roughly 19-fold higher revision rate (25% vs 1.3%) along with worse erosion and function — which is why the group now downsizes the head by one size as routine. 

What the cohort series add — and still cannot settle

These series add to the registries: all three devices produce within-patient PRO gains exceeding MCID, durable to 5–10 years, with infrequent revision. However, there is still no well-controlled comparison against aTSA or any other glenoid-sparing alternative.


Summary

What the evidence supports:

• Resurfacing PHR (McBride): no detectable difference in revision risk versus best-in-class aTSA in patients <65 with OA — on a research-restricted device that is not available in the U.S., with shorter followup and thinner data, adjusted for age and sex only.

• AOA Annual Report: Stemmed pyrocarbon hemiarthroplasty not different from anatomic TSA with respect to revision rate at up to 7 years in patients <60 with OA. 

• New Zealand registry: In comparison to conventional metal hemiarthroplasty, both pyrocarbon configurations are at least non-inferior; pyrocarbon may outperform metal hemi with respect to implant retention.

• Cohort series: For each device-and-technique combination studied, patient-reported and clinician scores rise from baseline by margins exceeding MCID and hold to 5–10 years — across the resurfacing device (Caughey), the U.S. stemmed implant (Griswold), and the European stemmed implant at five centers (Cointat, Garret, Boileau, Mathon, Kleim). 

What the current evidence does not support:

• Any comparative effectiveness with respect to patient reported outcomes. The registries do not report PROs; the cohort series report PROs with clinically significant preoperative to postoperative gains, but lack well-controlled studies comparing clinical benefit relative of pyrocarbon to aTSA or other glenoid-sparing alternatives.

Conclusion

Future clinical research is needed define the indications, the appropriate implants, the surgical technique, and the clinical outcomes for pyrocarbon humeral arthroplasty relative to other methods for managing glenohumeral arthritis.

While the gold standard for comparing surgical treatments is a prospective randomized controlled trial, this is difficult to accomplish with meaningful numbers in a procedure performed on relatively few, highly selected patients. Authors therefore turn to propensity matching to compare separately collected series. The approach carries two challenges. The first is deciding which characteristics to match on — diagnosis? Walch type? how the glenoid was managed? length of follow-up? age? sex? The variables that most influence the result, such as Walch type and glenoid management, are often the very ones not recorded in the comparison series, so they cannot be matched even in principle. The second is attrition: cases are lost both because stricter matching discards more unmatched cases and because missing data remove others, so the compared groups end up a fraction of the original cohorts — sometimes a small one — and no longer fully representative of them. The commentary by Sanchez-Sotelo is required reading on this point (Pyrocarbon Shoulder Hemiarthroplasty Seems to Outperform Metallic Hemiarthroplasty at a Short-Term Follow-up. JBJS Am2026;108(8):529–530. DOI: 10.2106/JBJS.25.01142)




There is work to be done


Pileated woodpecker


Follow on twitter/X: https://x.com/RickMatsen
Follow on facebook: https://www.facebook.com/shoulder.arthritis
Follow on LinkedIn: https://www.linkedin.com/in/rick-matsen-88b1a8133/

References

1. McBride A, Hurley R, Gill D, Du P, Duke P, Taylor F, Hoy G, Page R, Ross M. Outcomes of pyrolytic carbon humeral resurfacing hemiarthroplasty compared to best-in-class total shoulder arthroplasty in young patients with osteoarthritis: analysis from the Australian Orthopaedic Association National Joint Replacement Registry. J Shoulder Elbow Surg. 2026;35(5):1209–1218. doi:10.1016/j.jse.2025.09.007.

2. Australian Orthopaedic Association National Joint Replacement Registry. Hip, Knee and Shoulder Arthroplasty: 2025 Annual Report. Adelaide: AOA; 2025. Special Clinical Assessment: Shoulder Implant Choice — patients aged <60 years with OA (Table ST110, Figure ST77); data to 31 December 2024.

3. Gao R, Viswanath A, Frampton CM, Poon PC. Short-term outcomes following 159 stemmed pyrolytic carbon shoulder hemiarthroplasties and how they compare with conventional hemiarthroplasties and total shoulder arthroplasties in patients younger than 60 years with osteoarthritis: results from the New Zealand National Joint Registry. J Shoulder Elbow Surg. 2023;32(8):1594–1600. doi:10.1016/j.jse.2023.01.020.

4. Caughey MA, Penny I, Frampton CM. Medium-term results of the Ascension Pyrotitan surface replacement and Pyrocarbon hemiarthroplasty in the shoulder. Semin Arthroplasty JSES. 2024;34(1):1–10. doi:10.1053/j.sart.2023.01.005.

5. Griswold BG, Berger JM, Davis BP, Mauter L, Boyd M, Schuette HB, Johnston PS, Sears BW, Hatzidakis AM. Five-year radiographic and clinical outcomes of pyrocarbon hemiarthroplasty for glenohumeral arthritis and osteonecrosis. J Bone Joint Surg Am. 2025;107(24):2751–2762. doi:10.2106/JBJS.25.00163.

6. Cointat C, Raynier JL, Vasseur H, Lareyre F, Raffort J, Gauci MO, Boileau P. Short-term outcomes and survival of pyrocarbon hemiarthroplasty in the young arthritic shoulder. J Shoulder Elbow Surg. 2022;31(1):113–122. doi:10.1016/j.jse.2021.06.002.

7. Garret J, Cuinet T, Ducharne L, ReSurg, Godenèche A. Pyrocarbon humeral heads for hemishoulder arthroplasty grant satisfactory clinical scores with minimal glenoid erosion at 5-9 years of follow-up. J Shoulder Elbow Surg. 2024;33(2):328–334. doi:10.1016/j.jse.2023.06.021.

8. Boileau P, Cointat C, Raynier JL, Schippers P, Ranieri R. Pyrocarbon hemiarthroplasty for the treatment of shoulder osteoarthritis in young, active patients: survival and risk factors for revision. J Shoulder Elbow Surg. 2026;35(2):421–437. doi:10.1016/j.jse.2025.06.021.

9. Mathon P, Chivot M, Galland A, Airaudi S, Gravier R. Pyrolytic carbon head shoulder arthroplasty: CT scan glenoid bone modeling assessment and clinical results at 3-year follow-up. JSES Int. 2023;7:2476–2485. doi:10.1016/j.jseint.2023.06.028.

10. Kleim BD, Zolotar A, Hinz M, Nadjar R, Siebenlist S, Brunner UH. Pyrocarbon hemiprostheses show little glenoid erosion and good clinical function at 5.5 years of follow-up. J Shoulder Elbow Surg. 2024;33(1):55–64. doi:10.1016/j.jse.2023.05.027.

11. Lajoinie L, Garret J, van Rooij F, Saffarini M, Godenèche A. Pyrocarbon hemi-shoulder arthroplasty provides satisfactory outcomes following prior open Latarjet. J Shoulder Elb Arthroplast. 2024;8:24715492241292857. doi:10.1177/24715492241292857.

12. Barret H, Garret J, Favard L, Bonnevialle N, Collin P, Gauci MO, Boileau P. Long-term (minimum 10 years) survival and outcomes of pyrocarbon interposition shoulder arthroplasty. J Shoulder Elbow Surg. 2025;34:739–749. doi:10.1016/j.jse.2024.05.026.

13. U.S. Food and Drug Administration, Center for Devices and Radiological Health. De Novo Classification Request for Tornier Pyrocarbon Humeral Head — Decision Summary. DEN220012. Silver Spring, MD: FDA; granted December 16, 2022. (Regulatory decision file for IDE G140202; documents the propensity-subclassified historical cobalt-chrome control [Tornier Flex CoCr, n=169] from the Aequalis Post-Market Outcomes Registry. The composite-clinical-success analysis was subsequently published as Hatzidakis 2026, ref 14.)

14. Hatzidakis AM, Garrigues GE, Mauter LA, de Gast A, Venegoni MR, Yang Y, Johnston PS. Clinical Outcomes of Pyrocarbon Hemiarthroplasty: A Short-Term, Multicenter Study. J Bone Joint Surg Am. 2026;108(8):572–583. doi:10.2106/JBJS.25.00054. 

15. Sanchez-Sotelo J. Pyrocarbon Shoulder Hemiarthroplasty Seems to Outperform Metallic Hemiarthroplasty at a Short-Term Follow-up. Commentary on Hatzidakis et al. J Bone Joint Surg Am. 2026;108(8):529–530. doi:10.2106/JBJS.25.01142. (Independent JBJS commentary flagging the 43% missing control data as substantially weakening the study, the 2-year follow-up as very limited, the absence of radiographic assessment of humeral-head reconstruction, and the need to compare pyrocarbon HA with contemporary anatomic TSA using modern polyethylene.)



Friday, June 5, 2026

Pyrocarbon - the material rationale for its use in humeral arthroplasty - Section 3

3. The material rationale

A substantial part of the support for the clinical use of a pyrocarbon bearing surface in humeral arthroplasty rests on material properties demonstrated in laboratory studies. It is worth separating these properties from the possible clinical benefits inferred from them. Let's look at some of these studies.

Pyrolytic carbon is a graphite–carbon composite — the low-temperature isotropic (LTI) carbon that Bokros and colleagues developed at General Atomic in the 1960s and that has been the dominant bearing material for mechanical heart valves for roughly half a century.¹ Three of its properties are often used to justify its use as a shoulder bearing surface.

Elastic modulus close to bone. Pyrolytic carbon has a Young's modulus on the order of 20 GPa, within range of cortical bone (~15–20 GPa) and roughly an order of magnitude below cobalt-chromium (~210 GPa).² The argument is that a bearing surface whose stiffness approximates the bone it articulates against — rather than one ten times stiffer — transmits contact stress more physiologically and should therefore abrade subchondral bone less aggressively than metal.

Surface chemistry favorable to boundary lubrication. The load-bearing boundary lubricant of both native and prosthetic synovial joints is widely held to be surface-active phospholipid (SAPL), adsorbed as a film on the articular surface.³ Pyrolytic carbon's hydrophobic surface is hypothesized to adsorb these phospholipids and sustain the same boundary-lubrication film, lowering friction against bone. This is a frequently cited mechanism, but the pyrocarbon-specific link remains an inference from the general SAPL literature rather than a property directly demonstrated on the implant surface in vivo.

Reduced wear and favorable cell and tissue response, in vitro and in animals. In a shoulder wear simulator, the linearized bone-penetration rate, bone-volume-loss rate, and surface roughness for cobalt-chromium were roughly 30 times those for pyrocarbon; cobalt-chromium testing was halted at about 320,000 cycles because the bone interface had been consumed, whereas pyrocarbon ran to five million cycles.² In cultured chondrocytes, pyrocarbon supported cell growth without cytotoxicity and promoted type II collagen expression, generating a more cartilage-like matrix than either cobalt-chromium or plastic controls.⁴ An in vivo canine hip study found that cartilage articulating against LTI pyrocarbon showed significantly less gross wear, fibrillation, eburnation, glycosaminoglycan loss, and subchondral bone change than cartilage articulating against cobalt-chromium-molybdenum or titanium; survival analysis showed a 92% probability of cartilage survival against pyrocarbon at 18 months versus only 20% against either metal alloy.⁵ In a canine full-thickness-defect model, fibrocartilage regenerated at 86% of carbon-articulating defects versus 25% of metal, with surface cracking in 14% of carbon specimens versus 100% of metal.⁶

The clinical case built on these data is that pyrocarbon should generate less glenoid erosion than a metal hemiarthroplasty.

Two cautions should be considered. First, each finding presented above is preclinical — bench modulus, in vitro wear and cell culture, animal histology. None of it is, by itself, evidence of a potential patient-reported-outcome benefit exceeding the minimal clinically important difference relative to other bearing surfaces. Second, the material rationale describes the bearing surface only and does not necessarily predict the clinical performance of the implant itself.

Black Turnstone
Lopez Island


Follow on twitter/X: https://x.com/RickMatsen
Follow on facebook: https://www.facebook.com/shoulder.arthritis
Follow on LinkedIn: https://www.linkedin.com/in/rick-matsen-88b1a8133/

References

  1. Bokros JC. Carbon biomedical devices. Carbon. 1977;15(6):353–371.
  2. Klawitter JJ, Patton J, More R, Peter N, Podnos E, Ross M. In vitro comparison of wear characteristics of PyroCarbon and metal on bone: shoulder hemiarthroplasty. Shoulder Elbow. 2020;12(1 Suppl):11–22. doi:10.1177/1758573218796837. (Authors employed by / holding stock in the implant manufacturer.)
  3. Hills BA. Boundary lubrication in vivo. Proc Inst Mech Eng H. 2000;214(1):83–94. doi:10.1243/0954411001535264.
  4. Hannoun A, Ouenzerfi G, Brizuela L, Mebarek S, Bougault C, Hassler M, Berthier Y, Trunfio-Sfarghiu AM. Pyrocarbon versus cobalt-chromium in the context of spherical interposition implants: an in vitro study on cultured chondrocytes. Eur Cell Mater. 2019;37:1–15. doi:10.22203/eCM.v037a01.
  5. Cook SD, Thomas KA, Kester MA. Wear characteristics of the canine acetabulum against different femoral prostheses. J Bone Joint Surg Br. 1989;71(2):189–197.
  6. Kawalec JS, Hetherington VJ, Melillo TC, Corbin N. Evaluation of fibrocartilage regeneration and bone response at full-thickness cartilage defects in articulation with pyrolytic carbon or cobalt-chromium alloy hemiarthroplasties. J Biomed Mater Res. 1998;41(4):534–540.

Monday, June 1, 2026

Pyrocarbon in the Shoulder: what we think we know. Section 2

As a sequel to the prior post (Section 1), here is a look at the literature on clinical results for the pyrocarbon shoulder implants. Results can be expressed as (a) revision rate and (b) patient-reported outcomes (PRO). At the outset we recognize that lack of a revision is not the same as a clinically significant improvement (i.e., improvement in PRO that exceeds the minimal clinically important difference, MCID). Lack of a revision may result from patient unwillingness to undergo another procedure, patient lost to follow-up, poor patient health, or patient death — none of which indicate a clinically significant improvement.

An issue confounding the available clinical results for pyrocarbon implants is that reports often combine legacy devices, revised versions, and current instantiations.


PYRO TYPE 1: PROXIMAL HUMERAL RESURFACING (PHR/PYROTITAN)

This implant has been through at least three significant design iterations and three commercial sponsors. None of the published papers isolates the current implant configuration. Every survivorship figure in the literature pools generations. The lineage, reconstructed from the McBride 2026 paper [1], the Hoy 2026 paper [2], the Therapeutic Goods Administration hazard alert [3], and contemporaneous trade press, is summarized in the following table.


The McBride 2026 registry cohort (n = 403, enrolled 2004–2022) spans all three iterations; and the reported 35%-of-revisions-from-breakage figure averages performance across known-fracture-prone implants and the current design.[1] The Hoy 2026 cohort (n = 119, enrolled January 2013–November 2023) starts at about the time of the TGA hazard alert; the earliest patients received the first-redesign implant; mid-cohort patients received the second-redesign implant, and late patients received the current implant.[2] Thus, the result for the current commercially available PHR/PyroTITAN implant is unknown. It cannot be extracted from the existing literature because every published series pools at least two device generations.

Here is what relates to the post-2017 third design:

Survivorship:  cumulative percent revision (CPR) 7.7% at 10 yr (McBride 2026 [1]); 5-year Kaplan–Meier survivorship 97.5% (mean follow-up 34.6 months) (Hoy 2026 [2]). Manufacturer filings (not peer-reviewed): Kaplan–Meier survival ~86% up to ~117 mo as posted to ClinicalTrials.gov (NCT02405208 [9]). The primary endpoint of NCT02983292 [8] is device survival, not patient-reported outcomes; results are not yet published.

Effectiveness:  WOOS 38→83 and ASES 49→87, all exceeding MCID (Hoy 2026 [2]).


PYRO TYPE 2: THE U.S. STEMMED PYROCARBON HEMIARTHROPLASTY (HA-PYC)

The FDA Investigational Device Exemption study [4] enrolled patients between December 2015 and April 2017, before the final round of design changes. The De Novo clearance was granted in 2022, and U.S. commercial use of the pyrocarbon humeral head began only in March 2023. The Griswold 2025 JBJS paper [5] reports the IDE patients at 5 years, not the post-clearance commercial cohort.

Survivorship:  3 of 157 revised before 24 mo, mean follow-up 24.4 mo; 3-year Kaplan–Meier revision-free survival 96.6% (Hatzidakis 2026 [4]). In the same IDE lineage followed forward (n = 45, mean follow-up 73 mo), 7-year revision-free survival 95.7% and failure-free survival 93.4% — the 2 revisions were both for infection (Griswold 2025 [5]).

Effectiveness:  Composite Clinical Success 82.7%, defined as a ≥17-point Constant-score improvement without revision or device-related adverse event; ASES 44→88, adjusted Constant 51→91, SANE 36→85 (Hatzidakis 2026 [4]). At ≥5 years (mean 73 mo): ASES 47→96, SANE 39→94, Constant 48→88, all exceeding MCID, with glenoid morphology stable between the 2-year and final imaging (Griswold 2025 [5]).


PYRO TYPE 3: THE EUROPEAN STEMMED PYROCARBON HEMIARTHROPLASTY

The European cohort, followed a mean of 5.6 years [6], pools shoulders implanted before and after the systematic head-downsizing maneuver that became standard once Cointat reported that nonanatomic reconstruction (center of rotation > 3 mm off the anatomic center) occurred in 29% of cases and was strongly associated with glenoid erosion and revision [7].

With the current downsizing technique (Boileau 2026 [6]):

Survivorship:  revision-free survival 94% at 5 yr and 89% at 10 yr.

Effectiveness:  Constant 29→77, SSV 25%→84%, 91% return to work, 88% return to sport.


SUMMARY

Pyrocarbon shoulder arthroplasty is an exciting technology that is rapidly evolving. While evolution to address clinical issues (fracture, overstuffing, component malposition) is critical, it does confound the study of clinical outcomes: the implants on which follow-up data are available are often not the ones in current use. Once the designs and techniques have stabilized, data on revision rates and patient-reported outcomes for them will be of great interest.


Black vulture
San Antonio
2025


Follow on twitter/X: https://x.com/RickMatsen
Follow on facebook: https://www.facebook.com/shoulder.arthritis
Follow on LinkedIn: https://www.linkedin.com/in/rick-matsen-88b1a8133/


REFERENCES

1. McBride A, Hurley R, Gill D, Du P, Duke P, Taylor F, Hoy G, Page R, Ross M. Outcomes of pyrolytic carbon humeral resurfacing hemiarthroplasty compared to best-in-class total shoulder arthroplasty in young patients with osteoarthritis: analysis from the Australian Orthopaedic Association National Joint Replacement Registry. J Shoulder Elbow Surg. 2026;35(5):1209–1218. doi:10.1016/j.jse.2025.09.007.


2. Hoy G, Burrows K, McBride A, Ross M, Davis K, Warby S. PyroTITAN Pyrocarbon Shoulder Hemiarthroplasty: Clinical and Radiographic Outcomes with Medium-Term Follow-up. J Bone Joint Surg Am. Epub 2026 May 13. doi:10.2106/JBJS.25.00779.


3. Therapeutic Goods Administration. PyroTitan humeral resurfacing arthroplasty — hazard alert. Canberra, Australia: Australian Government Department of Health; August 2013. Available at: https://www.tga.gov.au/safety/recalls-and-other-market-actions/market-actions/pyrotitan-humeral-resurfacing-arthroplasty (LMT Surgical, 3% worldwide implant breakage rate, sub-surface fractures identified).


4. Hatzidakis AM, Garrigues GE, Mauter LA, de Gast A, Venegoni MR, Yang Y, Johnston PS. Clinical Outcomes of Pyrocarbon Hemiarthroplasty: A Short-Term, Multicenter Study. J Bone Joint Surg Am. 2026;108(8):572–583. doi:10.2106/JBJS.25.00054.


5. Griswold BG, Berger JM, Davis BP, Mauter L, Boyd M, Schuette HB, Johnston PS, Sears BW, Hatzidakis AM. Five-Year Radiographic and Clinical Outcomes of Pyrocarbon Hemiarthroplasty for Glenohumeral Arthritis and Osteonecrosis. J Bone Joint Surg Am. 2025;107(24):2751–2762. doi:10.2106/JBJS.25.00163.


6. Boileau P, Cointat C, Raynier JL, Schippers P, Ranieri R. Pyrocarbon hemiarthroplasty for the treatment of shoulder osteoarthritis in young, active patients: survival and risk factors for revision. J Shoulder Elbow Surg. 2026;35(2):421–437. doi:10.1016/j.jse.2025.06.021.


7. Cointat C, Raynier JL, Vasseur H, Lareyre F, Raffort J, Gauci MO, Boileau P. Short-term outcomes and survival of pyrocarbon hemiarthroplasty in the young arthritic shoulder. J Shoulder Elbow Surg. 2022;31(1):113–122. doi:10.1016/j.jse.2021.06.002.


8. ClinicalTrials.gov. A Clinical and Radiological Study to Evaluate the Safety and Efficacy of the PyroTITAN Humeral Resurfacing Arthroplasty (HRA) Device in a New Cohort of Patients After Product Re-Release (T-HRA-003). NCT02983292. Sponsor: Smith & Nephew. Completed February 2023; results posted to ClinicalTrials.gov 2024 (not peer-reviewed). https://clinicaltrials.gov/study/NCT02983292.


9. ClinicalTrials.gov. A Multi-center Outcomes Clinical Study of the PyroTITAN HRA Shoulder Implant in Humeral Head Resurfacing (CP-HRA-002). NCT02405208. Sponsor: Smith & Nephew. Enrollment 156; completed September 2023; results posted to ClinicalTrials.gov 2025 (not peer-reviewed). https://clinicaltrials.gov/study/NCT02405208.

Wednesday, May 27, 2026

Pyrocarbon in the Shoulder: what we think we know. Section 1 (more to come)

There have been some publications in the past eighteen months that have attracted attention: the FDA De Novo clearance for the stemmed Tornier pyrocarbon humeral head [1], the Hatzidakis IDE multicenter study [2], the McBride AOANJRR comparison of pyrocarbon humeral resurfacing against best-in-class anatomic total shoulder arthroplasty (aTSA) [3], the Griswold 5-year U.S. radiographic study with prospective Walch typing [4], and the Hoy PyroTITAN single-surgeon prospective cohort with disease-specific PROMs and Walch typing on every patient [5]. Together with the Boileau group’s HA-PYC survival and risk-factor analysis [6] and the Barret/Boileau 10-year interposition cohort [7], the evidence base is now sufficient to make some statements about these implants. With the help of Claude AI and Open Evidence I’ve tried to put together what we can glean from the literature.

Disclosure: I have not used a pyrocarbon implant in my 50+ years of practice (no first-hand experience). I have no relationship with any orthopaedic company. While I try to refrain from using proprietary names in my posts, I have done so here to clarify which implant is under discussion. My summary may contain errors and I would welcome corrections and comments. You may wish to compare this information to that in the prior post regarding the ream and run.

At least three different implant configurations

It seems that three distinct configurations of “pyrocarbon shoulder arthroplasty” have entered clinical practice:

• Pyrocarbon humeral resurfacing (PHR) / PyroTITAN: a stemless pyrocarbon resurfacing cap stabilized by a short central post seated on the prepared humeral head. The resurfacing cap is intended to solve two of the problems of the classic hemiarthroplasty technique: there is no metal collar/disc beneath the head that can oversize the construct, and there is no humeral stem that can malposition the bearing surface in height, version or inclination. The trade-off is the intrinsic risk of implant fracture— a failure mode identified during early device development that prompted design refinement and proof-testing after product re-release, and subject to a 2013 Therapeutic Goods Administration hazard alert [8]. This is the implant in the McBride 2022 [9], McBride 2026 [3], and Hoy 2026 [5] papers — the AOANJRR “PHR” label and the commercial “PyroTITAN” name refer to the same device class, which has undergone several design iterations under three sponsors (Ascension, Integra/LMT Surgical, Smith+Nephew). The implant is not FDA-cleared in the United States.





• Stemmed pyrocarbon hemiarthroplasty (HA-PYC / PyCHA). A conventional press-fit humeral stem (e.g. the Aequalis Ascend Flex) carrying a pyrocarbon head mounted on a metal Morse-taper tray. Humeral head excision and metaphyseal broaching are identical to other stemmed hemiarthroplasties; only the bearing surface differs. This construct retains the two technique vulnerabilities that resurfacing eliminates: the 1.5–2 mm metal disc beneath the pyrocarbon head effectively oversizes the construct (unless the surgeon systematically downsizes), and stem positioning errors in height, version or inclination can compound the oversizing. This is the implant in the European literature (Boileau, Cointat, Garret, Kleim, Ranieri) [6,10–13], the New Zealand registry [14], the Griswold U.S. five-year study [4], and the U.S. IDE study published in JBJS in April 2026 [2]. It is also the only configuration FDA-cleared in the U.S., via De Novo DEN220012 in late 2022 [1].

• Pyrocarbon interposition (PISA / InSpyre). A pyrocarbon spheroid with no humeral fixation. Largely supplanted by the stemmed head construct, but the Barret/Boileau 10-year PISA cohort [7] remains the only true long-term human data on any pyrocarbon shoulder implant.



The distinction matters for several reasons. First, the metaphyseal-preservation contention — that PHR may protect the rotator cuff blood supply because the arcuate artery is not violated [3] — applies to PHR/PyroTITAN and does not transfer to stemmed HA-PYC, where the head is excised. Second, the European mid-term PROM data (Constant, ASES, SSV, return-to-work, return-to-sport) come predominantly from stemmed HA-PYC series [6,10–13]. The Australian registry papers (McBride 2022, McBride 2026) report PHR survivorship without PROMs [3,9]. The Hoy 2026 paper is the only mid-term study with disease-specific PROMs (WOOS) and prospective Walch typing on every patient in the PHR/PyroTITAN configuration [5]. Third, the radiographic erosion data come from different measurement methods that are not directly comparable. Hoy reported mean medial glenoid erosion of 2.0 mm at 3 years following PHR (glenoid–medial spinoglenoid notch distance on Grashey radiographs) [5]; Griswold reported 2.9 mm at 2 years and 4.0 mm at 5+ years following stemmed HA-PYC (center-of-rotation to acromion–glenoid reference, with magnification correction) [4]. The absolute numbers cannot be compared across the two studies, but both constructs show most erosion in the first 1–2 years and substantial slowing thereafter [5,13]. Fourth, the FDA-cleared U.S. indication applies only to the stemmed construct and excludes inflammatory arthritis and total shoulder arthroplasty configurations [1] — a label restriction that would, for example, exclude the 4.2% inflammatory-arthritis cases in the Hoy PHR cohort [5]. Fifth, the implant-fracture history is specific to the PHR/PyroTITAN construct and is documented even in the contemporary design — Hoy reported one spontaneous fracture in 119 shoulders at 3 years (0.8%) [5], and the AOANJRR has tracked fracture-related revisions through three design iterations [3,9].

To summarize, the resurfacing-vs-stemmed decision can be thought of as a deliberate trade between two different failure modes. The stemmed construct carries a design-mediated, technique-modifiable failure mode: oversizing from the metal disc, plus stem malposition in height, version or inclination. Both drive nonanatomic reconstruction. Boileau and colleagues reported nonanatomic humeral reconstruction with oversizing of the pyrocarbon head in 24% of cases even in expert hands, and this single technical error was associated with roughly a 19-fold increase in revision risk (25% revision rate in the oversized subgroup vs. ~1.3% in the anatomic subgroup) and a 3.46-fold odds of progressive glenoid erosion (95% CI 1.13–10.55, P = .0295) [6]. The AOANJRR registry analyses align with this: the main reasons for revision in pyrocarbon HA were ongoing pain and implant fracture, in contrast to metal HA, where revisions were mostly for glenoid erosion [3,9,15]. The resurfacing construct eliminates the disc and the stem — and with them the oversizing and malposition problems — but introduces an implant-mediated failure mode: pyrocarbon head fracture, which the AOANJRR PHR cohort has tracked through three design iterations and which Hoy still observed in 0.8% of his contemporary series [5]. Both failure modes may be partly modifiable: the stemmed problem has been addressed by systematic downsizing — a surgeon-borne correction for a geometric perturbation introduced by the design itself; the resurfacing problem has been addressed by progressive design refinement and proof-testing improvements [5,8]. The jury is still out.

Follow on twitter/X: https://x.com/RickMatsen
Follow on facebook: https://www.facebook.com/shoulder.arthritis
Follow on LinkedIn: https://www.linkedin.com/in/rick-matsen-88b1a8133/


Black Oystercatcher


References

1. U.S. Food and Drug Administration. De Novo classification request for Tornier Pyrocarbon Humeral Head. DEN220012. Silver Spring (MD): Center for Devices and Radiological Health; 2022. https://www.accessdata.fda.gov/cdrh_docs/reviews/DEN220012.pdf

2. Hatzidakis AM, Garrigues GE, Mauter LA, de Gast A, Venegoni MR, Yang Y, Johnston PS. Clinical Outcomes of Pyrocarbon Hemiarthroplasty: A Short-Term, Multicenter Study. J Bone Joint Surg Am. 2026;108(8):572–583. doi:10.2106/JBJS.25.00054.

3. McBride A, Hurley R, Gill D, Du P, Duke P, Taylor F, Hoy G, Page R, Ross M. Outcomes of pyrolytic carbon humeral resurfacing hemiarthroplasty compared to best-in-class total shoulder arthroplasty in young patients with osteoarthritis: analysis from the Australian Orthopaedic Association National Joint Replacement Registry. J Shoulder Elbow Surg. 2026;35(5):1209–1218. doi:10.1016/j.jse.2025.09.007.

4. Griswold BG, Berger JM, Davis BP, Mauter L, Boyd M, Schuette HB, Johnston PS, Sears BW, Hatzidakis AM. Five-Year Radiographic and Clinical Outcomes of Pyrocarbon Hemiarthroplasty for Glenohumeral Arthritis and Osteonecrosis. J Bone Joint Surg Am. 2025;107(24):2751–2762. doi:10.2106/JBJS.25.00163.

5. Hoy G, Burrows K, McBride A, Ross M, Davis K, Warby S. PyroTITAN Pyrocarbon Shoulder Hemiarthroplasty: Clinical and Radiographic Outcomes with Medium-Term Follow-up. J Bone Joint Surg Am. Epub 2026 May 13. doi:10.2106/JBJS.25.00779.

6. Boileau P, Cointat C, Raynier JL, Schippers P, Ranieri R. Pyrocarbon hemiarthroplasty for the treatment of shoulder osteoarthritis in young, active patients: survival and risk factors for revision. J Shoulder Elbow Surg. 2026;35(2):421–437. doi:10.1016/j.jse.2025.06.021.

7. Barret H, Garret J, Favard L, Bonnevialle N, Collin P, Gauci MO, Boileau P. Long-term (minimum 10 years) survival and outcomes of pyrocarbon interposition shoulder arthroplasty. J Shoulder Elbow Surg. 2025;34(3):739–749. doi:10.1016/j.jse.2024.05.040.

8. Therapeutic Goods Administration. PyroTitan humeral resurfacing arthroplasty – hazard alert. Canberra, Australia: Australian Government Department of Health; 2013.

9. McBride AP, Ross M, Hoy G, Duke P, Page R, Peng Y, Taylor F. Mid-term outcomes of pyrolytic carbon humeral resurfacing hemiarthroplasty compared with metal humeral resurfacing and metal stemmed hemiarthroplasty for osteoarthritis in young patients: analysis from the Australian Orthopaedic Association National Joint Replacement Registry. J Shoulder Elbow Surg. 2022;31(4):755–762. doi:10.1016/j.jse.2021.08.017.

10. Cointat C, Raynier JL, Vasseur H, Lareyre F, Raffort J, Gauci MO, Boileau P. Short-term outcomes and survival of pyrocarbon hemiarthroplasty in the young arthritic shoulder. J Shoulder Elbow Surg. 2022;31(1):113–122. doi:10.1016/j.jse.2021.06.002.

11. Garret J, Cuinet T, Ducharne L, ReSurg, Godèneche A. Pyrocarbon humeral heads for hemishoulder arthroplasty grant satisfactory clinical scores with minimal glenoid erosion at 5–9 years of follow-up. J Shoulder Elbow Surg. 2024;33(2):328–334. doi:10.1016/j.jse.2023.06.021.

12. Kleim BD, Zolotar A, Hinz M, Nadjar R, Siebenlist S, Brunner UH. Pyrocarbon hemiprostheses show little glenoid erosion and good clinical function at 5.5 years of follow-up. J Shoulder Elbow Surg. 2024;33(1):55–64. doi:10.1016/j.jse.2023.05.027.

13. Ranieri R, Cointat C, Lacouture-Suarez JD, Boileau P. B2 and B3 glenoid osteoarthritis: outcomes of corrective and concentric (C2) reaming of the glenoid combined with pyrocarbon hemiarthroplasty. J Shoulder Elbow Surg. 2025;34(3):726–738. doi:10.1016/j.jse.2024.06.028.

14. Gao R, Viswanath A, Frampton CM, Poon PC. Short-term outcomes following 159 stemmed pyrolytic carbon shoulder hemiarthroplasties and how they compare with conventional hemiarthroplasties and total shoulder arthroplasties in patients younger than 60 years with osteoarthritis: results from the New Zealand National Joint Registry. J Shoulder Elbow Surg. 2023;32(8):1594–1600. doi:10.1016/j.jse.2023.01.020.

15. Khoriati AA, McBride AP, Ross M, Duke P, Hoy G, Page R, Holder C, Taylor F. Survivorship of shoulder arthroplasty in young patients with osteoarthritis: an analysis of the Australian Orthopaedic Association National Joint Replacement Registry. J Shoulder Elbow Surg. 2023;32(10):2105–2114.


Friday, May 22, 2026

The ream and run for active people with cuff-intact glenohumeral arthritis - what we think we know.


Disclosure: The author has no financial relationship with any orthopaedic device manufacturer.


================================================================


There is increasing interest in the use of hemiarthroplasty — rather than total shoulder arthroplasty (TSA) — in the management of cuff-intact arthritis. The ream-and-run (RnR) is a glenohumeral arthroplasty in which a cobalt-chromium humeral hemiarthroplasty is combined with conservative reaming of the glenoid bone to a single concentric concavity. The reamed bone remodels during the rehabilitation period to provide a biological bearing surface that articulates directly with the prosthetic head, eliminating the modes of failure unique to a prosthetic glenoid — wear, loosening, and bone loss. [1]

The radiograph above shows wear and loosening of a glenoid component with surrounding bone loss.


The RnR can enable high levels of shoulder function without the risk of plastic glenoid component failure.

It allows biological remodeling of challenging arthritic deformities such as the bad B2 shown below.

The RnR requires no proprietary planning software and no special components or instruments. It can be performed with most commercially available shoulder arthroplasty systems. The outcome depends on careful patient selection, attention to the details of surgical technique, and a dedication to the rehabilitation program. [1,2]


This is a review of what we think we know about the ream and run.


Sections:

1.  The Beginning

2.  Indications and Patient Selection

3.  Surgical Technique

4.  Time Course of Recovery

5.  Glenoid Wear and Radiographic Outcomes

6.  Comparison with Anatomic Total Shoulder Arthroplasty

7.  Complications and Reoperation

8.  Cost and Value

9.  Predictors of Success

10. Not for Every Patient, Every Surgeon, or Every Problem

11. Will the Outcomes for Pyrocarbon Hemiarthroplasty Be Different from Those for the RnR?

12. Conclusions


Additional information on the Ream and Run origins, patient and surgeon, surgery, rehabilitation, and results can be found at the ream and run website.


================================================================


1. THE BEGINNING


Recognition of the potential value of non-prosthetic glenoid arthroplasty emerged from observing that patients with failed total shoulder replacements recovered comfort and function after the worn or loosened polyethylene glenoid component was removed, leaving behind a smooth bony concavity.


In a canine model, the reamed glenoid bone became covered with conforming, securely attached fibrocartilaginous tissue at 24 weeks, with progressive subsurface trabecular bone densification consistent with physiologic load transfer. [20]



Slides above show (a) normal glenoid, (b) reamed glenoid, (c) surface regeneration at 12 wks, and (d) surface regeneration at 24 wks. 

Lynch and colleagues reported the first prospective RnR clinical series showing significant improvement in self-assessed comfort and function (mean SST 4.7 ± 2.4 preoperatively to 9.4 ± 2.6 at 2–4 year follow-up), with no surgical complications, no infections, no instability, and no revisions to total shoulder arthroplasty. [18] Another analysis compared RnRs with TSAs by the same surgeon, matched for diagnosis, sex, age, side, and follow-up duration. TSA reached its functional plateau 12 to 18 months earlier, but from 18 through 36 months mean SST scores did not differ significantly between procedures (36-month SST 9.5 vs 10.0). [21] This finding was confirmed by subsequent comparative studies. [8]


================================================================


2. INDICATIONS AND PATIENT SELECTION


RnR is an alternative to aTSA for patients with cuff-intact primary glenohumeral osteoarthritis, capsulorrhaphy arthropathy, or post-traumatic arthritis who wish to avoid the long-term limitations associated with a polyethylene glenoid component. [2] The prototypical RnR candidate is described as a motivated, resilient male patient with glenoid biconcavity and retroversion who wants to participate in heavy lifting and impact sports. [16] In the UW 544-case concurrent series, patients who chose RnR were more often male (92.0% vs 47.0%, p < .001), younger (mean 58 ± 9 vs 67 ± 10 years, p < .001), more likely to be married (83.2% vs 66.8%), more frequently from out of state (51.7% vs 21.7%), and significantly less likely to be on narcotic pain medication preoperatively (16.6% vs 26.6%, p = 0.005). [6] Their shoulders also differed: RnR patients had substantially higher prevalence of Walch B2 glenoids (46.0% vs 27.8%, p < .001), greater preoperative retroversion (19 ± 11° vs 15 ± 11°, p < .001), and higher preoperative SF-36 physical functioning scores (73 ± 17 vs 56 ± 23, p < .001) than aTSA patients. [6] In practice, RnR is the procedure offered to (and chosen by) the more biomechanically challenging shoulders in the more physically active patients.


Severe glenoid pathoanatomy does not preclude good outcomes. In a 49-shoulder cohort from an external high-volume center, 30 of 49 (61%) had Walch type B glenoids and patient-reported outcomes were not associated with Walch classification or with preoperative shoulder motion. [4] A matched-cohort analysis comparing RnR with aTSA likewise found no significant differences in outcome attributable to glenoid morphology after concentric reaming. [8]

Figure . RnR populations are enriched for B2 (biconcave) glenoids across institutions. (A) Distribution of Walch subtypes in 263 RnR and 281 aTSA patients at the University of Washington. [6] B2 glenoids — the morphology most often considered challenging for arthroplasty — are present in 46% of RnR patients but only 28% of aTSA patients at the same institution. (B) B2 prevalence converges across independent RnR cohorts (UW 46.0% [6]; Virginia Beach 41.0%, combined from 47 self-selecting and 31 control patients [19]), both well above the UW aTSA comparator (27.8%, dotted line). At every reporting center, RnR populations carry the more biomechanically challenging glenoid morphology.


================================================================


3. SURGICAL TECHNIQUE


The shoulder is approached through an anterior deltopectoral incision.


The subscapularis is peeled from the lesser tuberosity, retaining the capsule on the deep surface of the tendon.

A 360-degree release of the subscapularis restores the excursion of the muscle.

The humeral head is completely resected, avoiding an inadequate resection as shown on the left and protecting the rotator cuff as shown on the right. The plane of resection is 30 degrees of retroversion and 45 degrees with the long axis of the humeral shaft.

The glenoid is reamed with a nubbed (rather than cannulated) reamer. Reaming is conservative, only enough to establish a single concavity — prioritizing preservation of the glenoid bone stock. No attempt is made to alter glenoid version.

With the trial humeral component in place, the range of motion is verified, using the 150-40-50-60 guidelines: ≥150° of flexion, ≥40° external rotation with the subscapularis approximated to its reattachment site, ≥50% manual humeral translation, and 60° internal rotation in abduction. [1,2]

The subscapularis is securely repaired to the lesser tuberosity. Assisted forward flexion is started immediately after surgery to preserve the 150° of flexion achieved at surgery.

We inform the patient before surgery that if they have difficulty maintaining their range of motion, a manipulation under anesthesia with complete muscle relaxation can be considered.

================================================================


4. TIME COURSE OF RECOVERY

The recovery for each of the 12 Simple Shoulder Test functions at two years after surgery is shown below.


The trajectory of recovery after RnR is one of the most clinically useful pieces of preoperative counseling information. Gilmer and colleagues, analyzing 176 consecutive RnR procedures with longitudinal follow-up, demonstrated that shoulder comfort and function climb rapidly during the first year, continue to improve more slowly through the second year, and reach a steady state at approximately 20 months. [3] Among patients with at least 2 years of follow-up, 124 of 140 (89%) achieved the minimal clinically important difference (MCID) on the Simple Shoulder Test (SST). [3] The plateau is durable: Stenson and colleagues reported a mean SST of 10.2 at 5 years [5], and Sharareh and colleagues reported a mean SST of 10.3 with 82% of patients achieving MCID at 10 years [7].

Figure 2. Recovery trajectory and durability of patient-reported improvement after ream-and-run. Early time points (0–24 months) from Gilmer [3]; 5-year point from Stenson [5]; 10-year point from Sharareh [7]. Dotted vertical line marks the 20-month plateau.


================================================================


5. GLENOID WEAR AND RADIOGRAPHIC OUTCOMES


A historical objection to any humeral hemiarthroplasty has been that the prosthetic humeral head will progressively erode the glenoid, producing late pain and dysfunction. The modern quantitative wear literature does not support that objection.


Somerson and colleagues first characterized the clinical and radiographic course of RnR for primary glenohumeral osteoarthritis: medialization of the humeral head center of rotation occurs predominantly early and stabilizes, and radiographic medialization does not correlate with patient-reported outcomes. [9] Collins and colleagues extended this work in 113 RnR shoulders followed for a mean of 6.7 ± 2.3 years (range 4.2–11.4 years), measuring medialization on standardized AP radiographs. [10] The data were best fit by a quadratic function (R² = 0.82, p = .001) rather than a linear one: wear averaged 0.6 mm/year during the first 4 years and decelerated to 0.2 mm/year between years 4 and 10, reaching a cohort mean of 2.9 ± 4.3 mm at 6.7 years (Figure 3A). Wear was minimal or mild (≤5 mm) in 81% of patients, moderate (>5 to ≤10 mm) in 13%, and severe (>10 mm) in only 5% (Figure 3B).


The finding that matters clinically: wear severity did not predict patient-reported outcomes. SST, change in SST, VAS, and change in VAS were statistically indistinguishable between minimal/mild and moderate/severe wear cohorts (all p > 0.17). [10] Open revision rates were higher in the moderate/severe group (23.8% vs 7.6%, p = .004), but the absolute revision rate for the full cohort remained low at 10.6% over a mean of 6.7 years.

Figure 3. Glenoid wear after ream-and-run decelerates after year 4 and does not track with patient-reported outcomes (Collins 2026, n = 113, mean 6.7 yr follow-up). (A) Glenoid medialization over time. Curve = quadratic fit to longitudinal data (R² = 0.82, p = .001); dot = observed cohort mean at 6.7 years (2.9 mm); dotted reference line = expected trajectory if wear were linear at 0.3 mm/yr. Mean wear rate was 0.6 mm/yr during years 0–4 and 0.2 mm/yr during years 4–10. (B) Severity distribution at most recent follow-up: 81% minimal/mild (≤5 mm), 13% moderate (>5 to ≤10 mm), 5% severe (>10 mm); totals reflect rounding. Patient-reported outcomes (SST, ΔSST, VAS, ΔVAS) did not differ between mild and moderate/severe wear cohorts (all p > 0.17).


================================================================


6. COMPARISON WITH ANATOMIC TOTAL SHOULDER ARTHROPLASTY


Levins and colleagues conducted a propensity-matched cohort study comparing humeral-head replacement with concentric glenoid reaming (RnR) against aTSA in 39 matched pairs of younger patients (all male, <66 years of age, mean 58.6 ± 7.3 years; >75% with B- or C-type glenoids) at mean follow-up of 4.4 ± 2.3 years. [8] On paired t-tests, aTSA had statistically better final SST (10.9 vs 10.3) and ASES (89.9 vs 85.0) scores than RnR, but in the mixed-effects model that controlled for baseline covariates, arthroplasty type was not associated with any difference in PROM, HRQoL, or %MPI outcome. At 2 years, more aTSA patients achieved the MCID for VAS pain (89.7% vs 75%) and the SCB for ASES (100% vs 79.2%); however, at ≥5-year follow-up, MCID, SCB, and PASS achievement were statistically indistinguishable between cohorts on all three measures (SST, ASES, VAS pain). The Sharareh minimum 10-year analysis provides the parallel long-term picture: at the time horizon at which aTSA glenoid loosening typically becomes clinically relevant (9–14 years), RnR delivered SST and pain outcomes equivalent to aTSA without exposure to the prosthetic glenoid as a late failure mode. [7]


A JBJS commentary noted that the Levins analysis represents the largest comparative study of RnR outside the originating institution and the most rigorously matched comparison in the literature. [16] This commentary identifies limitations of the Levins propensity-score matching and argues that, on balance, these limitations strengthen rather than weaken the case for RnR equivalence. First, the matching algorithm could not capture activity level or psychosocial attributes such as resilience and motivation — characteristics that, if anything, favor the RnR cohort. If RnR patients are systematically more resilient (as Levins and colleagues subsequently demonstrated [15]) and the matched analysis still shows equivalence, the procedure is performing well before that resilience advantage is accounted for. Second, matching on duration of follow-up loaded the aTSA arm with more patients from the later (post-2011) period, when RnR was an option — so the aTSA cohort may include patients who actively chose aTSA over an available RnR alternative. Both limitations argue that the observed equivalence is a conservative estimate. [16]


The two procedures carry distinctly different risk profiles in time. In the Levins matched cohort, three RnR patients underwent revision for pain at a mean of 1.9 ± 1.7 years (two with positive Cutibacterium cultures at revision), while two aTSA patients required revision for glenoid loosening at 9.2 and 14 years. [8] RnR carries a higher early revision rate (largely for pain or stiffness within the first 2 years); aTSA defers risk to later glenoid-component failure. [7,8] A 544-case concurrent series likewise documented that, despite the marked differences in patient and shoulder characteristics, the two procedures produced clinically similar outcomes: mean 2-year SST of 10.0 ± 2.6 (RnR) vs 9.5 ± 2.7 (aTSA), with percent of maximum possible improvement of 72 ± 39% vs 73 ± 29%, respectively. [6]


A counterintuitive finding from the Levins inverse-probability-weighted sensitivity analysis of all 167 patients deserves note: dissatisfaction was significantly higher after aTSA (22.9%) than after RnR (9.4%), despite the higher RnR early revision rate. [8] The authors attribute this to either (1) the absence of postoperative activity restrictions for RnR patients, (2) deterioration in aTSA outcomes at longer follow-up in younger patients, (3) selection bias whereby patients with later aTSA problems are more likely to return for evaluation, or (4) that patients self-selecting RnR may also be more likely to rate themselves "satisfied" because of treatment-preference effects. The finding is only hypothesis-generating but it is consistent with the long-term equivalence findings.


Suttmiller, Snyder, and Carofino contributed independent confirmation from a single-surgeon practice outside the UW system: in a Virginia Beach cohort of 46 shoulders (23 RnR and 23 aTSA, all male, mean age 56.2 ± 8.3 years) matched 1:1, there were no differences in PROMs between RnR and aTSA at 1- and 2-year follow-up, although RnR patients reported significantly higher daily pain ratings (p = 0.047) and lower ASES scores (p = 0.031) at 3 months — consistent with the well-documented slower early recovery of RnR. [11]


Mostafa and colleagues subsequently performed a PRISMA-compliant systematic review and meta-analysis of comparative RnR versus aTSA studies (738 RnR / 810 aTSA across 8 studies). The pooled analysis found no significant differences between RnR and aTSA in SST, ASES, VAS, or forward flexion. A higher rate of return to theatre was reported for RnR (7.0%), consistent with the early-revision profile noted in the UW data. [12] An independent 2025 PRISMA meta-analysis by Roelker and colleagues, pooling 668 shoulders across three comparative studies, reached the same conclusion: significant pre-to-postoperative improvements in SST, ASES, VAS pain, and range of motion in both arms, with no statistically significant difference between RnR and aTSA in any outcome measure. The RnR revision rate (11.7%) was more than two and a half times that of aTSA (4.4%) when only short-term outcomes were considered. [17]

Figure 4. Convergent evidence for clinical equivalence between ream-and-run and anatomic total shoulder arthroplasty. Forest plot of mean SST difference (RnR − aTSA, 95% CI) across five independent comparative studies — a propensity-matched cohort [8], a single-institution long-term cohort [7], a non-UW matched comparison [11], and two PRISMA meta-analyses [12,17] totaling more than 2,200 patients across multiple study designs and institutions. None of the five comparisons reaches statistical significance; all confidence intervals cross zero. Both meta-analyses report higher short-term revision rates for RnR (7.0–11.7%) than aTSA (4.4%).


================================================================


7. COMPLICATIONS AND REOPERATION


Stiffness is the most common postoperative complication after RnR and the leading indication for early reoperation. Schiffman and colleagues analyzed 340 RnR patients and found a combined intervention rate of 17.9% (7.6% open revision plus 10.3% manipulation under anesthesia at mean follow-up of 2.1 years). On multivariate analysis, younger age (OR 0.96/year, p = 0.040), ASA class 1 compared with class 3 (OR 0.14, p = 0.020), and less passive forward elevation at the time of hospital discharge (OR 0.96/degree, p < 0.001) were independent predictors of reoperation for stiffness. [13] A clinically important secondary finding was that 69.2% (18 of 26) of patients undergoing open revision for stiffness had at least 2 positive intraoperative cultures for Cutibacterium — indicating that occult low-grade infection may be associated with stiffness and is one possible contributor among several to the observation that young, healthy patients appear more prone to reoperation for stiffness. [13] These data inform both patient selection and preoperative counseling: patients with these risk factors should be told explicitly that their probability of a second procedure for stiffness is higher than average, and surgeons should maintain a low threshold for sending intraoperative cultures at the time of any revision for stiffness. [13]


The complication landscape on the aTSA side looks very different, both in timing and in what failure looks like. aTSA carries failure modes distributed across the temporal spectrum rather than deferred to a single late peak. Of aTSA reoperations attributable to instability, rotator cuff failure, and infection, approximately 63% occur within the first 2 years. [23] After 2 years, aTSA fails at a steady linear rate of approximately 1.1% per year for all causes combined, with mechanical failure (aseptic loosening, component wear, and implant fracture) accumulating progressively and accounting for 41% of all aTSA reoperations (85 of 208), and rotator cuff failure accounting for an additional 22% (45 of 208). [23]


In the young patient population most directly relevant to the RnR comparison, the cumulative revision burden of aTSA is substantially higher than the often-cited general-population figures — Neyton's 202-patient cohort reaches 40% cumulative revision at 20 years, with glenoid failure accounting for 88% of revisions and a precipitous decline in survivorship after 10 years. [22] Severe glenoid wear after RnR, by contrast, is uncommon (5% in the Collins cohort [10]), and when it does occur it is not by itself an indication for revision in the absence of clinical symptoms. [9,10] Other historical young-patient series have reported similar long-term revision rates. [26–30]

Figure 5. Cumulative revision rate after primary anatomic total shoulder arthroplasty over 20 years. The red curve anchors the figure: Neyton 2019 [22] reports Kaplan-Meier survivorship of 95% / 83% / 60% at 5 / 10 / 20 years in 202 patients aged ≤60 undergoing primary aTSA for primary glenohumeral osteoarthritis, equivalent to cumulative revision rates of 5%, 17%, and 40%, with glenoid loosening accounting for 88% of revisions. The three gray curves are long-term comparators provided for context: Schoch 2015 [28] (minimum 20-year follow-up in patients aged <50, mixed diagnoses) and Evans 2021 [29] (minimum 20-year follow-up of the Aequalis prosthesis in a mixed-age cohort) each report cumulative revision rates of approximately 16% at 20 years; the Evans 2020 systematic review and meta-analysis [31] of case-series and national registry data pools mixed-age patients and reports approximately 8% at 10 years. The central observation is that the long-term revision burden of aTSA in young patients with primary osteoarthritis (Neyton 40% at 20 years) substantially exceeds the figures commonly cited from mixed-age long-term series (~16% at 20 years) and from registry pools (~8% at 10 years) — a difference of clinical importance when counseling younger active patients about the comparative durability of aTSA versus ream-and-run.

Figure 6. Revision risk after RnR and aTSA in younger patients: timing and consequence are not the same.


(A) Cumulative revision incidence over 20 years. The aTSA curve is anchored to Neyton 2019 [22], a multicenter Kaplan-Meier analysis of 202 patients aged ≤60 undergoing primary aTSA for primary glenohumeral osteoarthritis: 95% / 83% / 60% revision-free at 5 / 10 / 20 years, equivalent to cumulative revision rates of 5%, 17%, and 40%, with glenoid loosening accounting for 88% of revisions. The 40% at 20 years is at the upper end of published estimates; smaller long-term series in younger aTSA cohorts report revision rates of ≈16% at 20 years (Schoch 2015 [28]; Evans 2021 [29]), although Neyton's is the largest analysis and uses the most rigorous Kaplan-Meier methodology. The RnR open-revision curve is anchored to Schiffman 2023 [13] (7.6% at mean 2.1 years, n=340) and Sharareh 2024 [7] (12% at minimum 10 years, n=34). The aTSA curve crosses the RnR open-revision curve at approximately year 8. Manipulation under anesthesia is the dominant non-open intervention after RnR — Schiffman reports a combined intervention rate of 17.9% at 2.1 years (7.6% open plus 10.3% MUA), and Sharareh reports 14.7% combined at 10 years — but MUA involves no incision, no implant change, and no commitment to a different procedure, and is therefore not plotted on the cumulative revision curve. In the broader aTSA population, reoperations for instability, rotator cuff failure, and infection are concentrated in the first 2 years (63% of reoperations for these three causes combined occur within 2 years). [23,24]


(B) The asymmetry of revision. Equal cumulative revision rates between RnR and aTSA are not equal revision events. When an aTSA is revised, approximately 85% are converted to a reverse total shoulder arthroplasty [25]; the conversion is one-way, since the resected humeral head, the reamed glenoid, and the resurfaced subscapularis preclude re-creation of the original anatomic procedure. When an RnR is revised, the intervention is heterogeneous and largely conservative: in the Schiffman 2023 cohort [13], 35 of 61 intervention events (57%) were MUA only and 26 (43%) were open revisions, typically humeral-head exchange or debridement. Within the open-revision category, most revisions preserve the original procedure rather than escalate to a different one — Sharareh 2024 [7] reported four open revisions among 34 RnR patients at minimum 10-year follow-up: two head exchanges, two head downsizings, and zero conversions to aTSA or rTSA. An RnR revision typically leaves the patient with the original procedure intact and every downstream conversion option still available; an aTSA revision typically commits the patient to a fundamentally different procedure for life.

Figure 7. Indications for open revision among 508 RnRs at the University of Washington, plotted by date of index surgery. Each dot represents one open-revision event. Stiffness is the dominant indication throughout the series, particularly before 2017. After 2017, the overall frequency of open revision decreases and the indication mix shifts. The contributors to this temporal change are not known, but likely include refinements in patient selection, surgical technique, infection-prevention protocols, and rehabilitation.


================================================================


8. COST AND VALUE


Chawla and colleagues examined drivers of inpatient hospital cost and improvement in health-related quality of life across 222 aTSAs and 211 RnRs at a single institution. The RnR procedure was associated with lower inpatient cost — a finding that is straightforward: the RnR uses a single cobalt-chromium humeral head with no glenoid component, no cement, and no patient-specific planning software, so the implant-cost line item is materially smaller than in aTSA. Greater improvements in health-related quality of life were associated with lower preoperative SF-6D and EQ-5D scores and with higher preoperative optimism scores, in both procedures. [14]

Figure 8. Decomposition of inpatient hospital cost across three procedures: ream-and-run (RnR), anatomic total shoulder arthroplasty with standard polyethylene glenoid (aTSA standard), and anatomic TSA with augmented or patient-specific component (aTSA with augmented/PSI). Blue blocks represent cost categories shared across all three procedures and are scaled to typical proportions of total inpatient cost. Red blocks represent aTSA-specific categories absent in RnR — the polyethylene glenoid (added in all aTSA cases) and the augmented or patient-specific component (added in the subset that uses it). The structural cost differential between RnR and aTSA standard is approximately 20%; between RnR and aTSA with augmented/PSI, approximately 32%. Anchored to Chawla 2021 [14]; category proportions are illustrative and consistent with published shoulder arthroplasty cost-decomposition data.


================================================================


9. PREDICTORS OF SUCCESS


Across the literature, several patient factors are associated with favorable outcomes after RnR. Male sex is the most consistent predictor across all follow-up durations and PROMs. Lower preoperative SST scores identify patients with greater potential for measurable gain. Primary osteoarthritis as the diagnosis predicts better outcomes than post-traumatic or capsulorrhaphy arthropathy, and absence of prior shoulder surgery is associated with greater improvement and lower reoperation risk (p < 0.04). [3,5]


Psychosocial factors also matter. Levins, Dasari, and colleagues evaluated patient resilience and mental health as predictors of outcome and found that Connor-Davidson Resilience Scale scores and preoperative VR-12 Mental Component Scores were independently correlated with satisfaction (p < 0.05). [15] RnR patients demonstrated higher mean resilience scores than aTSA patients (34.3 ± 4.8 vs 32.5 ± 6.2, p < 0.001), suggesting that the procedure may attract — or require — more psychologically resilient individuals to navigate the long recovery. [15]


A common concern in the RnR literature is that published results are biased by patients self-selecting the procedure — travelling long distances, researching the technique independently, and pre-committing to a specific surgeon, all of which could plausibly inflate outcomes through a treatment-preference effect. Suttmiller, Snyder, and Carofino tested this hypothesis directly in 78 shoulders from their Virginia Beach practice, comparing the 47 shoulders in patients who deliberately sought out the surgeon and procedure (RnR_SS) against 31 shoulders in patients to whom the surgeon offered RnR after a standard arthroplasty consultation (RnR_CON). [19] Both groups achieved substantial improvements far exceeding the MCID threshold (SST MOI 84–89%, ASES MOI 78%, daily-pain MOI 76–80%) and 66 of 78 shoulders (85%) achieved MCID on all four outcome measures. There were no differences between self-selecting and control patients on any maximum-outcome-improvement metric, any MCID-achievement proportion, or subjective satisfaction (87.2% vs 80.6% "much better", p = 0.569).


Patients who are younger and those who have limited passive forward elevation at the time of hospital discharge are at higher risk of stiffness requiring reoperation and should be counseled accordingly, with attention to aggressive early-postoperative range-of-motion rehabilitation. [13]


Factors that do not predict outcomes include patient age, preoperative shoulder motion, and Walch glenoid classification (type A vs B). [3,4] Severe glenoid retroversion, biconcavity, and posterior subluxation should not, in themselves, be considered contraindications. [4,6]

Figure 9. Predictors of outcome after ream-and-run, synthesized across the cited literature. Positive predictors (top, blue) identify patient and shoulder characteristics associated with favorable outcomes on patient-reported measures and on revision-free survival, organized into demographic, diagnostic, and psychosocial categories. Neutral factors (middle, gray) have been tested in the published literature and found not to predict outcome — notable because several are commonly assumed to do so, including Walch glenoid type A vs B and patient self-selection, the most frequently cited objection to the RnR literature. Negative predictors (bottom, red) identify patient profiles in which RnR carries an elevated risk of stiffness reoperation specifically, not of inferior patient-reported outcome; these patients should be offered the procedure with explicit counseling about that risk and with attention to aggressive early-postoperative range-of-motion rehabilitation. Bar lengths are visual anchors only and do not represent effect sizes; citations indicate the source publications for each predictor.


================================================================


10. NOT FOR EVERY PATIENT, EVERY SURGEON, OR EVERY PROBLEM


A 2015 essay set out the limits of the RnR. RnR requires a patient willing to invest in a 20-month recovery and to commit to a daily home rehabilitation program; a surgeon experienced in conservative concentric reaming and soft-tissue balancing; and a clinical situation in which the trade-off — accepting a higher early revision risk in exchange for elimination of late prosthetic-glenoid complications — is clinically meaningful. [2]


================================================================


11. WILL THE OUTCOMES FOR PYROCARBON HEMIARTHROPLASTY BE DIFFERENT FROM THOSE FOR THE RnR?


As I emphasized in a prior blog post, answering this question will require a prospective trial that controls not only for important patient and shoulder characteristics, but also for the way the glenoid is managed (no glenoid work, selective burring, non-corrective reaming, corrective reaming), as well as humeral head size and position.


Here is my "back of the envelope" estimate. The MCID for the ASES score is between 6 and 14 points and the MCID for the SST is approximately 2 points. The standard deviation at 2 years is approximately 20 points for ASES and 3 points for SST. Assuming alpha = 0.05 (two-sided), 80% power, and 20% loss to follow-up at 2 years, between 100 and 400 matched pairs would be required to demonstrate superiority of either RnR or pyrocarbon hemiarthroplasty over the other, depending on which PROM and which MCID anchor is used. If patients are matched 1:1 on age (±5 years), sex, Walch type, and glenoid management, the cumulative match yield is roughly 25%, meaning initial enrollment would need to be approximately 4× the analyzable sample size — between 400 and 1,600 patients.


A non-inferiority design would be more tractable but would establish only that the implants perform similarly on PROMs — it would not address the comparative value (patient benefit per dollar) of the two procedures, which requires parallel cost analysis.


================================================================


12. CONCLUSIONS


The accumulated evidence supports the ream-and-run as a procedure that delivers durable patient-reported improvement for active patients with cuff-intact glenohumeral arthritis who wish to avoid the long-term risk of prosthetic glenoid failure. The original 2007 prospective series of Lynch and colleagues established the equivalence of self-assessed outcomes to anatomic total shoulder arthroplasty performed by the same surgeon at the same institution. [18] The 20-month recovery trajectory described by Gilmer [3] is reliably followed by a plateau that is sustained through 5 years (Stenson [5]) and 10 years (Sharareh [7]), with outcomes equivalent to aTSA in matched comparisons (Levins [8]), concurrent series [6], an independent external-center cohort (Suttmiller/Carofino [11]), and two pooled meta-analyses (Mostafa [12]; Roelker [17]). Modern quantitative wear data show modest, biphasic, and clinically silent medialization (Collins [10]). RnR is associated with lower inpatient costs (Chawla [14]) and patient resilience is a meaningful predictor of satisfaction (Levins JG [15]). The decision to perform a RnR should be grounded in the procedure's appropriate use — careful patient selection, dedicated technique, and committed rehabilitation — recognizing that it is not for every patient, every surgeon, or every problem. [2]













Getting a grasp


Common Yellowthroat
Union Bay Natural Area


Follow on twitter/X: https://x.com/RickMatsen
Follow on facebook: https://www.facebook.com/shoulder.arthritis
Follow on LinkedIn: https://www.linkedin.com/in/rick-matsen-88b1a8133/


================================================================


REFERENCES


1.  Matsen FA III, Carofino BC, Green A, Hasan SS, Hsu JE, Lazarus MD, McElvany MD, Moskal MJ, Parsons IM IV, Saltzman MD, Warme WJ. Shoulder hemiarthroplasty with nonprosthetic glenoid arthroplasty: the ream-and-run procedure. JBJS Reviews. 2021;9(8):e20.00243. doi:10.2106/JBJS.RVW.20.00243. PMID: 34432729.


2.  Matsen FA III. The ream and run: not for every patient, every surgeon or every problem. International Orthopaedics. 2015;39(2):255–261. doi:10.1007/s00264-014-2641-2. PMID: 25616729.


3.  Gilmer BB, Comstock BA, Jette JL, Warme WJ, Jackins SE, Matsen FA III. The prognosis for improvement in comfort and function after the ream-and-run arthroplasty for glenohumeral arthritis: an analysis of 176 consecutive cases. J Bone Joint Surg Am. 2012;94(14):e102. doi:10.2106/JBJS.K.00486. PMID: 22810409.


4.  Levins J, Passarelli E, Adkins J, Molino J, Henry H, Paxton ES, Green A. Early outcome of humeral head replacement with glenoid reaming arthroplasty (ream and run) for treatment of advanced glenohumeral osteoarthritis. J Shoulder Elbow Surg. 2022;31(9):1846–1858. doi:10.1016/j.jse.2022.01.152. PMID: 35276348.


5.  Stenson JF, Collins AP, Yao JJ, Sharareh B, Whitson AJ, Matsen FA III, Hsu JE. Factors associated with success of ream-and-run arthroplasty at a minimum of 5 years. J Shoulder Elbow Surg. 2023;32(6S):S85–S91. doi:10.1016/j.jse.2023.01.024. PMID: 36813226.


6.  Matsen FA III, Whitson A, Jackins SE, Neradilek MB, Warme WJ, Hsu JE. Ream and run and total shoulder: patient and shoulder characteristics in five hundred forty-four concurrent cases. International Orthopaedics. 2019;43(9):2105–2115. doi:10.1007/s00264-019-04352-8. PMID: 31240359.


7.  Sharareh B, Whitson AJ, Matsen FA III, Hsu JE. Minimum 10-year follow-up of anatomic total shoulder arthroplasty and ream-and-run arthroplasty for primary glenohumeral osteoarthritis. J Shoulder Elbow Surg. 2024;33(6):1276–1284. doi:10.1016/j.jse.2023.08.028. PMID: 37777045.


8.  Levins J, Molla V, Adkins J, Molino J, Pasarelli E, Paxton ES, Green A. Comparison of humeral-head replacement with glenoid-reaming arthroplasty (ream and run) versus anatomic total shoulder arthroplasty: a matched-cohort study. J Bone Joint Surg Am. 2023;105(7):509–517. doi:10.2106/JBJS.22.00650. PMID: 36727972.


9.  Somerson JS, Neradilek MB, Service BC, Hsu JE, Russ SM, Matsen FA III. Clinical and radiographic outcomes of the ream-and-run procedure for primary glenohumeral arthritis. J Bone Joint Surg Am. 2017;99(15):1291–1304. doi:10.2106/JBJS.16.01201. PMID: 28763415.


10. Collins AP, Sheth MM, Stenson JF, Kahsai EA, Khoo KJ, Ogunleye T, Whitson AJ, Matsen FA III, Hsu JE. Characterizing glenoid wear after hemiarthroplasty with concentric glenoid reaming: a study of 113 arthroplasties at a mean of 6.7 years of follow-up. J Shoulder Elbow Surg. 2026;35(5):995–1002. Epub 2025 Oct 8. PMID: 41072717.


11. Suttmiller AMB, Snyder BA, Carofino BC. Comparison of short- and midterm outcomes in patients following ream-and-run and anatomic total shoulder arthroplasties. J Shoulder Elbow Surg. 2025;34(3):794–802. doi:10.1016/j.jse.2024.06.011. PMID: 39103085.


12. Mostafa OES, Jordan RW, Thangarajah T, MacLean S, Woodmass J, D'Alessandro P, Malik SS. Ream-and-run technique offers equivalent clinical outcomes as anatomical total shoulder arthroplasty but with a high rate of complications: a systematic review and meta-analysis. J Orthop. 2025;63:206–215. doi:10.1016/j.jor.2025.04.003. PMID: 40303354.


13. Schiffman CJ, Jurgensmeier K, Yao JJ, Wu JC, Whitson AJ, Jackins SE, Matsen FA III, Hsu JE. Risk factors for stiffness requiring intervention after ream-and-run arthroplasty. JB JS Open Access. 2023;8(2):e22.00104. doi:10.2106/JBJS.OA.22.00104. PMID: 37123506.


14. Chawla SS, Whitson AJ, Schiffman CJ, Matsen FA III, Hsu JE. Drivers of lower inpatient hospital costs and greater improvements in health-related quality of life for patients undergoing total shoulder and ream-and-run arthroplasty. J Shoulder Elbow Surg. 2021;30(8):e503–e516. doi:10.1016/j.jse.2020.10.030. PMID: 33271324.


15. Levins JG, Dasari SP, Quinlan NJ, Whitson AJ, Matsen FA III, Hsu JE. Anatomic shoulder arthroplasty: the correlation between patient resilience, mental health, and outcome. J Shoulder Elbow Surg. 2024;33(6S):S9–S15. doi:10.1016/j.jse.2024.03.008. PMID: 38548096.


16. Hsu JE. Can we reliably compare outcomes of ream-and-run and anatomic total shoulder arthroplasty? Commentary on an article by James Levins, MD, et al.: "Comparison of humeral-head replacement with glenoid-reaming arthroplasty (ream and run) versus anatomic total shoulder arthroplasty. A matched-cohort study." J Bone Joint Surg Am. 2023;105(7):e21. doi:10.2106/JBJS.23.00034. PMID: 37017618.


17. Roelker L, Ghasemi A, Fabregas A, Shafer G, Raphael J. Ream and run hemiarthroplasty versus total shoulder arthroplasty: a comparison of shoulder treatments for glenohumeral arthritis. Cureus. 2025;17(7):e88813. doi:10.7759/cureus.88813. PMID: 40861556.


18. Lynch JR, Franta AK, Montgomery WH Jr, Lenters TR, Mounce D, Matsen FA III. Self-assessed outcome at two to four years after shoulder hemiarthroplasty with concentric glenoid reaming. J Bone Joint Surg Am. 2007;89(6):1284–1292. doi:10.2106/JBJS.E.00942. PMID: 17545432.


19. Suttmiller AMB, Snyder BA, Carofino BC. Patient self-selection does not influence postoperative improvements in pain, function, or satisfaction in ream-and-run arthroplasty patients. J Shoulder Elbow Surg. 2026;35(4):989–994. doi:10.1016/j.jse.2025.08.006. PMID: 40868275.


20. Matsen FA III, Clark JM, Titelman RM, Gibbs KM, Boorman RS, Deffenbaugh D, Korvick DL, Norman AG, Ott SM, Parsons IM IV, Sidles JA. Healing of reamed glenoid bone articulating with a metal humeral hemiarthroplasty: a canine model. J Orthop Res. 2005;23(1):18–26. doi:10.1016/j.orthres.2004.06.019. PMID: 15607870.


21. Clinton J, Franta AK, Lenters TR, Mounce D, Matsen FA III. Nonprosthetic glenoid arthroplasty with humeral hemiarthroplasty and total shoulder arthroplasty yield similar self-assessed outcomes in the management of comparable patients with glenohumeral arthritis. J Shoulder Elbow Surg. 2007;16(5):534–538. doi:10.1016/j.jse.2006.11.003. PMID: 17509900.


22. Neyton L, Kirsch JM, Collotte P, Collin P, Gossing L, Chelli M, Walch G. Mid- to long-term follow-up of shoulder arthroplasty for primary glenohumeral osteoarthritis in patients aged 60 or under. J Shoulder Elbow Surg. 2019;28(9):1666–1673. doi:10.1016/j.jse.2019.03.006. PMID: 31202630.


23. Schoch B, Werthel JD, Schleck CD, Harmsen WS, Sperling J, Sánchez-Sotelo J, Cofield RH. Optimizing follow-up after anatomic total shoulder arthroplasty. J Shoulder Elbow Surg. 2017;26(6):997–1002. doi:10.1016/j.jse.2016.10.024. PMID: 28109672.


24. Werner BC, Burrus MT, Begho I, Gwathmey FW, Brockmeier SF. Early revision within 1 year after shoulder arthroplasty: patient factors and etiology. J Shoulder Elbow Surg. 2015;24(12):e323–e330. doi:10.1016/j.jse.2015.05.035. PMID: 26163282.


25. Gauci MO, Cavalier M, Gonzalez JF, Holzer N, Baring T, Walch G, Boileau P. Revision of failed shoulder arthroplasty: epidemiology, etiology, and surgical options. J Shoulder Elbow Surg. 2020;29(3):541–549. doi:10.1016/j.jse.2019.07.034. PMID: 31594726.


26. Denard PJ, Raiss P, Sowa B, Walch G. Mid- to long-term follow-up of total shoulder arthroplasty using a keeled glenoid in young adults with primary glenohumeral arthritis. J Shoulder Elbow Surg. 2013;22(7):894–900. doi:10.1016/j.jse.2012.09.016. PMID: 23312293.


27. Walch G, Moraga C, Young A, Castellanos-Rosas J. Results of anatomic nonconstrained prosthesis in primary osteoarthritis with biconcave glenoid. J Shoulder Elbow Surg. 2012;21(11):1526–1533. doi:10.1016/j.jse.2011.11.030. PMID: 22445158.


28. Schoch B, Schleck C, Cofield RH, Sperling JW. Shoulder arthroplasty in patients younger than 50 years: minimum 20-year follow-up. J Shoulder Elbow Surg. 2015;24(5):705–710. doi:10.1016/j.jse.2014.07.016. PMID: 25306496.


29. Evans JP, Batten T, Bird J, Thomas WJ, Kitson JB, Smith CD. Survival of the Aequalis total shoulder replacement at a minimum 20-year follow-up: a clinical and radiographic study. J Shoulder Elbow Surg. 2021;30(10):2355–2360. doi:10.1016/j.jse.2021.01.038. PMID: 33675966.


30. Deshmukh AV, Koris M, Zurakowski D, Thornhill TS. Total shoulder arthroplasty: long-term survivorship, functional outcome, and quality of life. J Shoulder Elbow Surg. 2005;14(5):471–479. doi:10.1016/j.jse.2005.02.009. PMID: 16194737.


31. Evans JP, Evans JT, Craig RS, Mohammad HR, Sayers A, Blom AW, Whitehouse MR, Rees JL. How long does a shoulder replacement last? A systematic review and meta-analysis of case-series and national registry reports with more than 10 years of follow-up. Lancet Rheumatol. 2020;2(9):e539–e548. doi:10.1016/S2665-9913(20)30226-5.