These authors point out the evidence that intervertebral disc degeneration can be induced by Propionibacterium acnes (P. acnes).
They analyzed the pathological changes in degenerated human intervertebral discs infected with P. acnes, finding that compared with P. acnes-negative samples, P. acnes-positive discs showed increased apoptosis of nucleus pulposus cells concomitant with severe intervertebral disc degeneration.
They then established a P. acnes inoculated intervertebral disc degeneration animal model, finding that severe intervertebral disc degeneration was induced by P. acnes infection by promoting nucleus pulposus cell apoptosis.
Their results suggested that P.acnes-induced apoptosis of nucleus pulposus cells via the Toll-like receptor 2 (TLR2)/c-Jun N terminal kinase (JNK) pathway and mitochondrial-mediated cell death.
Furthermore P. acnes was found to activate autophagy (the orderly degradation and recycling of cellular components), which likely plays a role in apoptosis of nucleus pulposus cells
Overall, these findings further validated the involvement of P. acnes in the pathology of intervertebral disc degeneration and provided evidence that P. acnes-induced apoptosis of nucleus pulposus cells via the TLR2/JNK pathway is likely responsible for the pathology of intervertebral disc degeneration
Comment: While this study concerns intervertebral disc degeneration caused by Propionibacterium, it elucidates the mechanism by which this bacteria can destroy tissue. This same mechanism may be involved in the destruction of bone and soft tissue by this organism in failed arthroplasty and cuff repair.
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The reader may also be interested in these posts:
Consultation for those who live a distance away from Seattle.
Click here to see the new Shoulder Arthritis Book.
Click here to see the new Rotator Cuff Book
Information about shoulder exercises can be found at this link.
Use the "Search" box to the right to find other topics of interest to you.
You may be interested in some of our most visited web pages including:shoulder arthritis, total shoulder, ream and run, reverse total shoulder, CTA arthroplasty, and rotator cuff surgery as well as the 'ream and run essentials'
See from which cities our patients come.
See the countries from which our readers come on this post.
