Saturday, June 20, 2020

Shoulder periprosthetic infection: single stage or two-stage revision?

Single-stage versus two-stage revision for shoulder periprosthetic joint infection: a systematic review and meta-analysis

These authors point out that an evidence-based algorithm for treatment of shoulder PJI is lacking in current practice. They conducted a comprehensive literature review to identify studies that reported on single stage revision (13 studies) or two-stage revision (30 studies) with infection eradiation and a minimum follow-up of 12-months and minimum of five patients for analysis.

In the single stage studies, the most common organisms were Cutibacterium (49%), Coagulase-negative Staph (23%), methicillin sensitive staph (11%), methicillin resistant staph (3%). 10% were polymicrobial.

In the two stage studies, the most common organisms were Cutibacterium (34%), Coagulase-negative Staph (20%), methicillin sensitive staph (17%), methicillin resistant staph (10%). 6% were polymicrobial.

The reinfection rate for single stage was 6.3% and 10.1% for two-stage revision (p=0.40). 

The authors point out that the recommendations of the International Conference for Periprosthetic Infection (see this link) included a consensus definition for shoulder PJI derived through systematic literature review and a Delphi process: "Definite PJI can be identified by the presence of a sinus tract, intraarticular pus or two positive cultures with phenotypically identical organisms."

Comment: As the authors point out, it is difficult to diagnose a definite PJI non-operatively (i.e. without taking cultures or finding pus at surgery unless there is a sinus tract).  It is even more difficult to diagnose a "re-infection" without re-operation. Because the most common infecting organism, Cutibacterium, typically does not produce clinical or laboratory signs of inflammation (elevated temperature, WBC, ESR), diagnosing a Cutibacterium re-infection is especially difficult due to their subtle clinical presentation.

Since infections can become evident years after surgery (see this link), a 12 month followup is likely to miss some of them.

Unless there is gross pus or a draining sinus, our approach for an infected arthroplasty is a single stage revision to an impaction allografted hemiarthroplasty, see this link.

For an important example, click on this link.

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We have a new set of shoulder youtubes about the shoulder, check them out at this link.

Be sure to visit "Ream and Run - the state of the art" regarding this radically conservative approach to shoulder arthritis at this link and this link

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