These authors conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and retrospective cohort studies (RCS) that compared outcomes of patients who did and did not receive tranexamic acid (TXA)
The primary outcome was transfusion rate, and secondary outcomes were changes in hemoglobin, estimated total blood loss (ETBL), blood loss via drainage, operative time, hospital stay, overall complications, and thromboembolic events.
They identified 3 RCTs and 3 RCS including 677 patients with 680 shoulders (343 TXA and 337 non-
TXA). The random-effects model meta-analysis showed that TXA group had a lower transfusion rate, less change in hemoglobin, and reduced estimated blood loss, especially in patients with RTSA.
All six included studies reported data on the proportion of patients who developed complications and thromboembolic events during the study period. There were no significant differences in overall complications or thromboembolic events between the TXA and the non-TXA groups.
They identified 3 RCTs and 3 RCS including 677 patients with 680 shoulders (343 TXA and 337 non-
TXA). The random-effects model meta-analysis showed that TXA group had a lower transfusion rate, less change in hemoglobin, and reduced estimated blood loss, especially in patients with RTSA.
All six included studies reported data on the proportion of patients who developed complications and thromboembolic events during the study period. There were no significant differences in overall complications or thromboembolic events between the TXA and the non-TXA groups.
Comment: It is uncommon for our patients to need a transfusion after a shoulder arthroplasty. In our view, the principal rationale for tranexamic acid is to reduce bleeding into the arthroplasty after surgery - such bleeding can increase pain and interfere with the achievement of early range of motion. We use one dose at the beginning and one at the end of the case. Contraindications for us are prior thromboembolic events, evidence of coronary artery or cerebrovascular disease, and diagnosis of cancer.
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The reader may also be interested in these posts:
Consultation for those who live a distance away from Seattle.
Click here to see the new Shoulder Arthritis Book.
Click here to see the new Rotator Cuff Book
Information about shoulder exercises can be found at this link.
Use the "Search" box to the right to find other topics of interest to you.
You may be interested in some of our most visited web pages including:shoulder arthritis, total shoulder, ream and run, reverse total shoulder, CTA arthroplasty, and rotator cuff surgery as well as the 'ream and run essentials'
See from which cities our patients come.
See the countries from which our readers come on this post.
The reader may also be interested in these posts:
Consultation for those who live a distance away from Seattle.
Click here to see the new Shoulder Arthritis Book.
Click here to see the new Rotator Cuff Book
Information about shoulder exercises can be found at this link.
Use the "Search" box to the right to find other topics of interest to you.
You may be interested in some of our most visited web pages including:shoulder arthritis, total shoulder, ream and run, reverse total shoulder, CTA arthroplasty, and rotator cuff surgery as well as the 'ream and run essentials'
See from which cities our patients come.
See the countries from which our readers come on this post.
