Tyrosol is a quorum-sensing molecule (that is, a molecule that regulates cell-to-cell communication) present in olive oil and produced by Candida albicans. It is an inexpensive natural phenolic compound with substantial antimicrobial/antibiofilm activity against multiple aerobic microorganisms. The authors suggest that this molecule has low cytotoxicity.
These authors examined the in vitro effectiveness of Tyrosol (alone or in combination with antibiotics) in inhibiting Cutibacterium acnes planktonic growth and in reducing C. acnes biofilm formation on roughened titanium alloy disks.
The rationale behind the use of titanium alloy was that this particular biomaterial presents a higher affinity for C. acnes adhesion when compared with stainless steel and cobalt chromium. There is evidence of a correlation between roughness of biomaterials and degree of bacterial attachment.
They found that
Comment: The titanium alloy from which most humeral implants are made are known to encourage the formation of Cutibacterium biofilms. The concept of coating implants to prevent these biofilms is of great interest. However, at present an effective coating has yet to be identified.
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They found that
(1) Tyrosol was effective in inhibiting C. acnes planktonic (free-floating) growth and that there was synergy with rifampicin.
(2) A hydrogel coating with Tyrosol showed no difference in the inhibition of free-floating (planktonic) C. acnes over control.
(2) A hydrogel coating with Tyrosol showed no difference in the inhibition of free-floating (planktonic) C. acnes over control.
(3) Loaded hydrogel with tyrosol was no more effective than control in reducing C. acnes biofilm formation.
(4) Soluble Tyrosol inhibited biofilm formation compared to control.
They concluded that although the implant coating with hydrogel (either pure or supplemented with antimicrobial agents) did not diminish C. acnes biofilm development in vitro, soluble tyrosol at 597 mg/mL (1 M) exceeded the meaningful biofilm inhibition threshold of 80%.
(4) Soluble Tyrosol inhibited biofilm formation compared to control.
They concluded that although the implant coating with hydrogel (either pure or supplemented with antimicrobial agents) did not diminish C. acnes biofilm development in vitro, soluble tyrosol at 597 mg/mL (1 M) exceeded the meaningful biofilm inhibition threshold of 80%.
It is of interest to see the resistance of C. acnes to Clindamycin and Cipro
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